CDK4 Polyclonal antibody (11026-1-AP)
Cell division protein kinase 4; CMM3; cyclin dependent kinase 4; Cyclin-dependent kinase 4; EC:2.7.11.22
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HeLa cells, rat pancreas tissue, HepG2 cells, MCF-7 cells, NIH/3T3 cells |
| Positive IP detected in | HeLa cells |
| Positive IHC detected in | human lung cancer tissue, human breast cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | MCF-7 cells |
| Positive FC (Intra) detected in | MCF-7 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Cyclin-dependent kinase-4 (CDK4) is a protein-serine kinase involved in the cell cycle. It is essential for the G1- to S-phase transition during the cell cycle and its expression is primarily controlled at the transcriptional level(PMID:17253961). CCND1-CDK4 axis is not only critical in glial tumor cells but also in stromal-derived cells in the surrounding tumor microenvironment that are vital to sustain tumor outgrowth(PMID:21844184).
文献引用 (187)
F-box protein FBXO32 ubiquitinates and stabilizes D-type cyclins to drive cancer progression.
F-box 蛋白 FBXO32 泛素化并稳定 D 型细胞周期蛋白，从而驱动癌症进展
The LINC01315-encoded small protein YAPer-ORF competes with PRP4k to hijack YAP signaling to aberrantly promote cell growth.
LINC01315 编码的小蛋白 YAPer-ORF 与 PRP4k 竞争，劫持 YAP 信号传导，从而异常地促进细胞生长
Cooperation between the Hippo and MAPK pathway activation drives acquired resistance to TEAD inhibition
Hippo 和 MAPK 通路激活之间的协同作用推动了对 TEAD 抑制的获得性抗性
SAE1 promotes tumor cell malignancy via SUMOylation and liquid-liquid phase separation facilitated nuclear export of p27.
SAE1 通过 SUMO 化和液-液相分离促进 p27 的核输出，从而促进肿瘤细胞恶性转化
Mechanism of D-type cyclin recognition by the AMBRA1 E3 ligase receptor.
AMBRA1 E3 连接酶受体识别 D 型细胞周期蛋白的机制
Combined therapy with DR5-targeting antibody-drug conjugate and CDK inhibitors as a strategy for advanced colorectal cancer
DR5靶向抗体药物偶联物与CDK抑制剂联合治疗作为晚期结直肠癌的一种策略
DARS2 Promotes Bladder Cancer Progression by Enhancing PINK1-Mediated Mitophagy.
DARS2 通过增强 PINK1 介导的线粒体自噬促进膀胱癌进展
Decursin induces FLT3-ITD acute myeloid leukemia cell apoptosis by increasing the expression of the ubiquitin-conjugase UBE2L6.
Decursin 通过增加泛素结合酶 UBE2L6 的表达来诱导 FLT3-ITD 急性髓系白血病细胞凋亡
DNMT3a promotes LUAD cell proliferation and metastasis by activating the HDAC7 signalling pathway
DNMT3a通过激活HDAC7信号通路促进肺腺癌细胞增殖和转移
METTL3 regulates Ambra1 expression in an m6A-YTHDF2-dependent manner to promote mantle cell lymphoma progression.
METTL3 以 m6A-YTHDF2 依赖的方式调节 Ambra1 的表达，从而促进套细胞淋巴瘤的进展
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