COXIV Polyclonal antibody (11242-1-AP)
COX4I1; COX IV-1; COX4; Cytochrome c oxidase subunit 4 isoform 1; mitochondrial
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HeLa cells, HEK-293 cells, HepG2 cells, rat brain tissue, rat liver tissue, mouse heart tissue, mouse liver tissue, mouse lung tissue, Jurkat cells, NIH/3T3 cells, mouse skeletal muscle tissue, MCF-7 cells |
| Positive IP detected in | mouse skeletal muscle tissue |
| Positive IHC detected in | human prostate cancer tissue, human pancreas cancer tissue, human heart tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | HepG2 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
COX4I1, also named as COX4 and COXIV-1, belongs to the cytochrome c oxidase IV family. It is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. COX4I1 is a marker for mitochondria. It has two isoforms (isoform 1 and 2). Isoform 1(COX4I1) is ubiquitously expressed and isoform 2 is highly expressed in lung tissues. COX4I1 is commonly used as a loading control. This antibody was generated against full length COX4I1 protein and cross reacts with COX4I2.
文献引用 (187)
Nonenzymatic lysine D-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses
由乙二醛酶 II 底物 SLG 诱导的非酶促赖氨酸 D-乳酰化可抑制炎症免疫反应
Dental pulp stem cells alleviate Schwann cell pyroptosis via mitochondrial transfer to enhance facial nerve regeneration
牙髓干细胞通过线粒体转移缓解雪旺细胞焦亡以增强面神经再生
PNPLA6 regulates retinal homeostasis by choline through phospholipid turnover
PNPLA6 通过磷脂周转，利用胆碱调节视网膜稳态。
RONIN/HCF1-TFEB Axis Protects Against D-Galactose-Induced Cochlear Hair Cell Senescence Through Autophagy Activation.
RONIN/HCF1-TFEB轴通过自噬激活来抵抗D-半乳糖诱导的耳蜗毛细胞衰老
Harnessing tissue-derived mitochondria-rich extracellular vesicles (Ti-mitoEVs) to boost mitochondrial biogenesis for regenerative medicine.
利用组织来源的富含线粒体的细胞外囊泡（Ti-mitoEVs）促进线粒体生物合成，用于再生医学
Calcium dysregulation disrupts mitochondrial homeostasis by interfering AMPK/Drp1 pathway to aggravate plaque progression and instability
钙稳态失衡会干扰 AMPK/Drp1 通路，从而破坏线粒体稳态，加剧斑块进展和不稳定性。
Homocysteine induced N(6)-methyldeoxyadenosine modification perturbation elicits mitochondria dysfunction contributes to the impairment of learning and memory ability caused by early life stress in rats.
同型半胱氨酸诱导的 N(6)-甲基脱氧腺苷修饰扰动引起线粒体功能障碍，导致大鼠早期生活压力引起的学习和记忆能力受损
Targeting mitochondrial complex I of CD177+ neutrophils alleviates lung ischemia-reperfusion injury
靶向CD177+中性粒细胞的线粒体复合物I可减轻肺缺血再灌注损伤。
Exogenous SPD inhibits trastuzumab-mediated cardiomyocyte pyroptosis through SIRT3-regulated mitochondrial quality control.
外源性 SPD 通过 SIRT3 调节的线粒体质量控制抑制曲妥珠单抗介导的心肌细胞焦亡
Metformin Alleviates Liver Metabolic Dysfunction in Polycystic Ovary Syndrome by Activating the Ethe1/Keap1/PINK1 Pathway.
二甲双胍通过激活 Ethe1/Keap1/PINK1 通路缓解多囊卵巢综合征的肝脏代谢功能障碍
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