IGF2BP2 Polyclonal antibody (11601-1-AP)
IGF2 mRNA-binding protein 2; IGF-II mRNA-binding protein 2; IMP2; IMP-2; insulin like growth factor 2 mRNA binding protein 2
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HeLa cells, HepG2 cells, mouse kidney tissue, rat kidney tissue, human kidney tissue, human heart tissue, COLO 320 cells |
| Positive IP detected in | HEK-293 cells |
| Positive IHC detected in | human pancreas cancer tissue, human breast cancer tissue, human colon cancer tissue, mouse stomach tissue, mouse brain tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | HepG2 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Insulin-like growth factor 2 mRNA-binding protein 2(IGF2BP2), ia a member of a family of mRNA binding protein, which can bind to several mammalian cells' mRNAs. Thus it may involve in the regulation of translation of mRNA. IGF2BP2's polymorphisms is risk factor for developing type 2 diabetes. This antibody raise against part of N-terminus of human IGF2BP2. IGF2BP2 has some isoforms with the MW of 54-66 kDa. Some literature has reported that multiple bands can be detected (PMID: 22427968, 36322753, 23069990).
文献引用 (104)
The Long Noncoding RNA LINC02820 Promotes Tumor Growth and Metastasis Through Regulating MYH9 Expression in Esophageal Squamous Cell Carcinoma.
长链非编码RNA LINC02820通过调控食管鳞状细胞癌中MYH9的表达促进肿瘤生长和转移
METTL16 Promotes Lipid Metabolic Reprogramming and Colorectal Cancer Progression.
METTL16促进脂质代谢重编程和结直肠癌进展
ZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer.
ZC3H13 介导 SNTB1 的 N6-甲基腺苷修饰，从而促进胃癌的上皮-间质转化
A circular RNA overcomes acquired resistance to BET inhibitors by antagonizing IGF2BP2-mediated c-MYC translation in TNBC.
环状 RNA 通过拮抗 TNBC 中 IGF2BP2 介导的 c-MYC 翻译来克服对 BET 抑制剂的获得性耐药性
N6-methyladenosine Reader IGF2BP2-modified HMMR Promotes Non-small Cell Lung Cancer Metastasis via Interaction with MAP4K4
N6-甲基腺苷读取蛋白IGF2BP2修饰的HMMR通过与MAP4K4相互作用促进非小细胞肺癌转移
METTL3 inhibition promotes radiosensitivity in hepatocellular carcinoma through regulation of SLC7A11 expression
METTL3 抑制通过调节 SLC7A11 表达促进肝细胞癌的放射敏感性
METTL14-mediated m6A modification of ZFP14 inhibits clear cell renal cell carcinoma progression via promoting STAT3 ubiquitination
METTL14 介导的 ZFP14 m6A 修饰通过促进 STAT3 泛素化抑制透明细胞肾细胞癌进展
SENP1-mediated deSUMOylation of YBX1 promotes colorectal cancer development through the SENP1-YBX1-AKT signaling axis.
SENP1介导的YBX1去SUMO化通过SENP1-YBX1-AKT信号轴促进结直肠癌的发展
Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia.
病理性α-突触核蛋白失调表观转录组写入蛋白METTL3，从而驱动小胶质细胞中的神经炎症
IGF2BP2 binding to CPSF6 facilitates m6A-mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer.
IGF2BP2 与 CPSF6 结合，促进 m6A 介导的 PUM2 的替代多聚腺苷酸化，并促进卵巢癌的恶性进展
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