用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | A431 cells, HEK-293 cells, Jurkat cells |
| Positive IP detected in | HEK-293 cells |
| Positive IHC detected in | human breast cancer tissue, human kidney tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | MCF-7 cells |
| Positive FC (Intra) detected in | MCF-7 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
ELAVL1, also named as HUR, belongs to the RRM elav family. It is involved in 3'-UTR ARE-mediated MYC stabilization. ELAVL1 binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, ELAVL1 binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs.
文献引用 (52)
Circular RNA TFRC/SCD1 mRNA interaction regulates ferroptosis and metastasis in gastric cancer.
环状RNA TFRC/SCD1 mRNA相互作用调控胃癌的铁死亡和转移
BAP31-ELAVL1-SPINK6 axis induces loss of cell polarity and promotes metastasis in hepatocellular carcinoma
BAP31-ELAVL1-SPINK6 轴诱导细胞极性丧失并促进肝细胞癌转移
Deciphering the role of ELAVL1: Insights from pan-cancer multiomics analyses with emphasis on nasopharyngeal carcinoma.
解读 ELAVL1 的作用：从泛癌多组学分析中获得的见解，重点关注鼻咽癌
ELAVL1-mediated USP29 mRNA degradation activates TAK1 driving M1 microglial polarization and neural stem cell differentiation dysregulation in spinal cord injury.
ELAVL1 介导的 USP29 mRNA 降解激活 TAK1，驱动脊髓损伤中的 M1 小胶质细胞极化和神经干细胞分化失调
Enhancing mRNA translation efficiency by introducing sequence optimized AU-rich elements in 3' UTR via HuR anchorage.
通过 HuR 锚定在 3' UTR 中引入序列优化的富含 AU 的元件，从而提高 mRNA 翻译效率
Hypoxia-induced circPLOD2a/b promotes the aggressiveness of glioblastoma by suppressing XIRP1 through binding to HuR
缺氧诱导的 circPLOD2a/b 通过与 HuR 结合抑制 XIRP1，从而促进胶质母细胞瘤的侵袭性。
Adipose-specific HuR deletion protects against high-fat diet-induced obesity in mice through upregulating Ucp1 expression.
脂肪组织特异性 HuR 缺失可通过上调 Ucp1 表达来保护小鼠免受高脂饮食引起的肥胖
Kuiyangling Enema Alleviates Ulcerative Colitis Mice by Reducing Levels of Intestinal NETs and Promoting HuR/VDR Signaling
溃炎灵灌肠剂通过降低肠道NETs水平、促进HuR/VDR信号传导缓解溃疡性结肠炎小鼠
A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs.
通过核转位线粒体lncRNA介导的线粒体到细胞核的调控
RNA binding protein HuR regulated by OIP5-AS1 may be involved in maternal transcript degradation during the human maternal-to-zygotic transition.
受 OIP5-AS1 调控的 RNA 结合蛋白 HuR 可能参与人类母体向合子转变过程中的母体转录本降解
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