用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HEK-293 cells, HeLa cells, Jurkat cells, MCF-7 cells, MDA-MB-231 cells, NIH/3T3 cells |
| Positive IHC detected in | human renal cell carcinoma tissue, human breast cancer tissue, human colon cancer tissue, human placenta tissue, human prostate cancer tissue, human tonsillitis tissue, mouse colon tissue, rat colon tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | HeLa cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Y box binding protein 1(YBX1) is one of cis-acting elements which has a role in regulation of the expression of HLA class II genes. YBX1 is great of importance in regulation of PTP1B expression. It can bind to splice sites mediate pre-mRNA alternative splicing regulation. Also, it involves the regulation of translation by modulation of the interaction between the mRNA and eukaryotic initiation factors. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation. The calculated molecular weight of YBX1 is 36 kDa, but modified YBX1 is about 36-56 kDa (PMID: 27384875 ). Recently, researchers developed a biomimetic nanoplatform to deliver RNA piR-RCC specifically into RCC tumors. This RNA interacts with YBX1 to inhibit tumor proliferation and metastasis (PMID: 40411401).
文献引用 (47)
Loss of MNX1 Sensitizes Tumors to Cytotoxic T Cells by Degradation of PD-L1 mRNA.
MNX1 的缺失通过降解 PD-L1 mRNA 使肿瘤对细胞毒性 T 细胞更加敏感
N4-Acetylcytidine-Mediated CD2BP2-DT Drives YBX1 Phase Separation to Stabilize CDK1 and Promote Breast Cancer Progression.
N4-乙酰胞苷介导的CD2BP2-DT驱动YBX1相分离以稳定CDK1并促进乳腺癌进展
The TMBIM1-YBX1 axis orchestrates MDSC recruitment and immunosuppressive microenvironment in pancreatic cancer.
TMBIM1-YBX1 轴协调胰腺癌中 MDSC 的募集和免疫抑制微环境
o8G-modified circKIAA1797 promotes lung cancer development by inhibiting cuproptosis.
o8G修饰的circKIAA1797通过抑制铜凋亡促进肺癌发展
The SOX12-YBX1-LDHA signaling axis drives metastasis in papillary thyroid carcinoma.
SOX12-YBX1-LDHA信号轴驱动乳头状甲状腺癌的转移
RNA-targeted proteomics identifies YBX1 as critical for efficient HCMV mRNA translation.
RNA靶向蛋白质组学鉴定出YBX1对于HCMV mRNA的有效翻译至关重要
CILP1 interacting with YBX1 promotes hypertrophic scar formation by suppressing PPARs transcription
CILP1与YBX1相互作用，通过抑制PPARs转录促进肥厚性瘢痕形成。
Aberrant downregulation of Y-box binding protein 1 expression impairs the cell cycle in an m(5)C-dependent manner in human granulosa cells from patients with primary ovarian insufficiency.
原发性卵巢功能不全患者的人类颗粒细胞中，Y-box 结合蛋白 1 表达的异常下调以 m(5)C 依赖的方式损害细胞周期
5-methylcytosine regulated CCNL2 promotes tumorigenesis and cisplatin resistance of ovarian cancer with therapeutic implications.
5-甲基胞嘧啶调控的CCNL2促进卵巢癌的肿瘤发生和顺铂耐药性，具有治疗意义
Menin regulates YBX1 nucleus translocation to boost the HKDC1 transcription and affects pancreatic cancer glycolysis.
Menin 调节 YBX1 核转位以促进 HKDC1 转录，并影响胰腺癌的糖酵解
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