GSDMD Polyclonal antibody (20770-1-AP)
FKSG10; gasdermin D; Gasdermin domain-containing protein 1; gasderminD; Gasdermin-D
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | A431 cells, Jurkat cells, THP-1 cells, AC16 cells |
| Positive IP detected in | THP-1 cells |
| Positive IHC detected in | human ovary cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | HeLa cells, A431 cells, PC-3 cells |
| Positive FC (Intra) detected in | Jurkat cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
GSDMD is a 53 kDa cytosolic protein and a member of the gasdermin protein family, which features 6 members in humans (GSDMA, -B, -C, -D, -E and -F. GSDMD was identified as the executioner of inflammasome-associated pyroptosis. Caspase-1, -11, or -4 cleave GSDMD after an aspartate residue within a central linker domain (D275 in humans and D276 in mice) to generate a 31-kDa N-terminal GSDMD fragment (GSDMD-NT) and a 22-kDa C-terminal fragment (GSDMD-CT). In addition to the canonical 31/22 kDa cleavage products, a 43 kDa fragment has been observed under specific experimental or pathological conditions. The generation of the 43 kDa fragment was observed upon caspase-3 and -7 activation during apoptosis. This antibody can only detect full-length GSDMD.
文献引用 (123)
Neoadjuvant Chemotherapy With Cisplatin Up-Regulates GSDMD to Enhance Oral Squamous Cell Carcinoma Metastasis Through MMP14-Mediated EMT Activation.
顺铂新辅助化疗通过 MMP14 介导的 EMT 激活上调 GSDMD，从而增强口腔鳞状细胞癌的转移
Clemastine fumarate accelerates accumulation of disability in progressive multiple sclerosis by enhancing pyroptosis.
富马酸克莱马斯汀通过增强细胞焦亡加速进行性多发性硬化症患者的残疾程度
HOXC8 impacts lung tumorigenesis by preventing pyroptotic cell death through the suppression of caspase-1 expression.
HOXC8 通过抑制 caspase-1 的表达来阻止细胞焦亡，从而影响肺肿瘤的发生
JC124 confers multimodal neuroprotection in epilepsy by suppressing NLRP3 inflammasome activation: evidence from animal and human neuronal models.
JC124 通过抑制 NLRP3 炎症小体激活，在癫痫中发挥多模式神经保护作用：来自动物和人类神经元模型的证据
Targeting ceramide-induced microglial pyroptosis: Icariin is a promising therapy for Alzheimer's disease.
靶向神经酰胺诱导的小胶质细胞焦亡：淫羊藿苷是治疗阿尔茨海默病的一种有前景的疗法
β-elemene promotes ferroptosis to improve the sensitivity of imatinib in gastrointestinal stromal tumours by targeting N6AMT1.
β-榄香烯通过靶向 N6AMT1 促进铁死亡，从而提高伊马替尼对胃肠道间质瘤的敏感性
PRDM16 suppresses pyroptosis to attenuate the progression of AKI caused by rhabdomyolysis via upregulation of USP10.
PRDM16 通过上调 USP10 抑制细胞焦亡，从而减轻横纹肌溶解引起的 AKI 的进展
Sinomenine alleviates neuroinflammation in chronic cerebral hypoperfusion by promoting M2 microglial polarization and inhibiting neuronal pyroptosis via exosomal miRNA-223-3p
青藤碱通过促进M2型小胶质细胞极化和抑制神经元焦亡（通过外泌体miRNA-223-3p介导），从而减轻慢性脑低灌注引起的神经炎症。
Verteporfin inhibits the cGAS-STING pathway and improves the tumor microenvironment during cisplatin treatment in hepatocellular carcinoma.
维替泊芬抑制 cGAS-STING 通路，改善肝细胞癌顺铂治疗期间的肿瘤微环境
Osteopontin regulates right ventricular failure through integrin ανβ3/PERK/CHOP-dependent inflammatory and apoptotic pathways.
骨桥蛋白通过整合素αβ3/PERK/CHOP依赖的炎症和凋亡途径调节右心室衰竭
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