用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | mouse kidney tissue, human skeletal muscle tissue |
| Positive IP detected in | mouse kidney tissue |
| Positive IHC detected in | human kidney tissue, mouse testis tissue, human small intestine tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | human kidney tissue, mouse kidney tissue |
| Positive IF-Fro detected in | mouse kidney tissue |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
ACE2 (Angiotensin-converting enzyme 2), also named as ACEH, is a zinc metalloprotease of the ACE family and a critical regulator of the reninangiotensin system. ACE2 has a more restricted tissue distribution than ACE, being found predominantly in the heart, kidneys, and testes although low levels have been detected in a variety of tissues (PMID:15983030). ACE2 has been shown to be a functional receptor of the human coronaviruses SARS-CoV and SARS-CoV-2 (PMID: 32142651). The expression level and expression pattern of human ACE2 in different tissues might be critical for the susceptibility, symptoms, and outcome of 2019-nCoV/SARS-CoV-2 infection (PMID: 32133153). It can be used as a potential therapeutic target of SARS-CoV-2 (PMID: 32125455). The calculated molecular weight of ACE2 is 92kDa but it migrates to 120kDa due to N-glycosylation (PMID:16166094). Sometimes, several cleaved fragments can also be detected as 75kDa, 50 kDa or 37kDa (PMID: 29561187, 22009550, 30759273). It has 2 isoforms produced by alternative splicing. This antibody is specific to ACE2. The location of ACE2 is membrane and cytoplasm, however it accumulates in the nucleus during the mitosis (PMID: 1730413/PMID: 18292088).
文献引用 (73)
Evolution of Omicron lineage towards increased fitness in the upper respiratory tract in the absence of severe lung pathology
在没有严重肺部病理的情况下，Omicron 谱系向上呼吸道适应性增强的方向进化
Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy.
利用 2D 和 3D 人类子宫内膜细胞培养模型研究 SARS-CoV-2 在妊娠早期的感染情况
Interleukin-1 prevents SARS-CoV-2-induced membrane fusion to restrict viral transmission via induction of actin bundles
白细胞介素-1 通过诱导肌动蛋白束阻止 SARS-CoV-2 诱导的膜融合，从而限制病毒传播
LIN28A-dependent lncRNA NEAT1 aggravates sepsis-induced acute respiratory distress syndrome through destabilizing ACE2 mRNA by RNA methylation
LIN28A 依赖的 lncRNA NEAT1 通过 RNA 甲基化破坏 ACE2 mRNA 的稳定性，加重脓毒症引起的急性呼吸窘迫综合征
Direct interaction of HMGB1 with SARS-CoV-2 facilitates its infection via RAGE-dependent endocytosis
HMGB1与SARS-CoV-2的直接相互作用通过RAGE依赖性内吞作用促进其感染。
Exosomes derived from syncytia induced by SARS-2-S promote the proliferation and metastasis of hepatocellular carcinoma cells
SARS-2-S诱导的合体来源的外泌体促进肝癌细胞增殖和转移
Syntaxin-6 restricts SARS-CoV-2 infection by facilitating virus trafficking to autophagosomes.
Syntaxin-6 通过促进病毒向自噬体运输来限制 SARS-CoV-2 感染
Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca(2+) intracellular signaling cascade.
冠状病毒的刺突蛋白通过刺激 Src/PI3K/AKT/Ca(2+) 细胞内信号级联激活肥大细胞脱颗粒
Long-term exposure to high-altitude hypoxic environments reduces blood pressure by inhibiting the renin-angiotensin system in rats.
长期暴露于高海拔缺氧环境会通过抑制大鼠的肾素-血管紧张素系统来降低血压
Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes
去唾液酸糖蛋白受体1促进SARS-CoV-2感染人类正常肝细胞
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