用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HepG2 cells, HEK-293 cells, L02 cells, MCF-7 cells, MDA-MB-231 cells, U-937 cells |
| Positive IHC detected in | human liver cancer tissue, human colon cancer tissue, human gliomas tissue, human pancreas tissue, human placenta tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | human ovary tumor tissue |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
LAMP1 (also known as CD107a) is a 90-120 kDa heavily glycosylated membrane protein enriched in the lysosomal membrane. LAMP1 functions to provide selectins with carbohydrate ligands. This protein has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells and may also play a role in tumor cell differentiation and metastasis.
文献引用 (64)
Programmed enhancement of endogenous iron-mediated lysosomal membrane permeabilization for tumor ferroptosis/pyroptosis dual-induction.
程序性增强内源性铁介导的溶酶体膜通透性，以诱导肿瘤铁死亡/焦亡双重发生
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration.
分子伴侣介导的自噬指导双重机制，以平衡过早衰老和衰老细胞清除，从而防止椎间盘退变
USP25 ameliorates vascular remodeling by deubiquitinating FOXO3 and promoting autophagic degradation of FOXO3
USP25通过去除FOXO3的泛素化并促进FOXO3的自噬降解来改善血管重塑。
Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degeneration
分子伴侣介导的自噬对 PLCG1 的降解受损会促进细胞衰老和椎间盘退化
Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke
OTUB2介导的RIPK3去泛素化增强缺血性卒中后的神经元坏死性凋亡。
Moxibustion ameliorates abnormal subchondral bone remodeling by promoting ACSL1-mediated autophagy to degrade NLRP3 in osteoarthritis.
艾灸通过促进 ACSL1 介导的自噬降解 NLRP3，从而改善骨关节炎中异常的软骨下骨重塑
The ROGDI protein mutated in Kohlschutter-Tonz syndrome is a novel subunit of the Rabconnectin-3 complex implicated in V-ATPase assembly.
Kohlschutter-Tonz 综合征中发生突变的 ROGDI 蛋白是 Rabconnectin-3 复合物的一个新亚基，与 V-ATPase 组装有关
Bioinformatics analysis and preliminary validation of autophagy-related genes in asthma disease.
生物信息学分析及哮喘疾病中自噬相关基因的初步验证
The cholesterol metabolite 25-hydroxycholesterol suppresses porcine deltacoronavirus via lipophagy inhibition and mTORC1 modulation
胆固醇代谢产物25-羟基胆固醇通过抑制脂质自噬和调节mTORC1来抑制猪δ冠状病毒。
ERâα36 knockdown is associated with lysosomal dysfunction and proliferation inhibition in liver cancer cells.
ER-α36 敲低与肝癌细胞溶酶体功能障碍和增殖抑制有关
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