YTHDF2 Polyclonal antibody (24744-1-AP)
CLL associated antigen KW 14; CLL-associated antigen KW-14; DF2; HGRG8; NY REN 2
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HEK-293 cells, Jurkat cells, HeLa cells, MOLT-4 cells, NIH/3T3 cells, C6 cells, Raji cells |
| Positive IP detected in | HeLa cells |
| Positive IHC detected in | mouse brain tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | mouse brain tissue |
| Positive IF/ICC detected in | U2OS cells, HeLa cells, sodium arsenite treated HeLa cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
YTHDF2 also named as CLL associated antigen KW 14 or HGRG8 is a 579 amino acid protein, which contains one YTH domain and exists as two alternatively spliced isoforms. YTHDF2 is expressed in in pancreas, testis and placenta. YTHDF2 may play a role in human longevity. Due to the high sequence similarity, 24744-1-AP is likely to cross-react with both YTHDF1 and YTHDF3.
文献引用 (201)
YTHDF2 promotes ATP synthesis and immune evasion in B cell malignancies
YTHDF2促进B细胞恶性肿瘤中的ATP合成和免疫逃逸。
Helicobacter pylori CagA elevates FTO to induce gastric cancer progression via a "hit-and-run" paradigm.
幽门螺杆菌 CagA 通过“打了就跑”的模式上调 FTO 以诱导胃癌进展
YTHDC1 cooperates with the THO complex to prevent RNA-damage-induced DNA breaks
YTHDC1与THO复合物协同作用，防止RNA损伤诱导的DNA断裂。
The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy.
SOX18 的 m6A 修饰导致脓毒症诱发的心肌病中 PTX3 增加和心肌细胞焦亡
VIRMA-mediated m(6)A modification regulates forebrain formation through modulating ribosome biogenesis.
VIRMA 介导的 m(6)A 修饰通过调节核糖体生物合成来调控前脑的形成
Nuclear accumulation of YTHDF1 regulates mRNA splicing in the DNA damage response.
YTHDF1 的核内积累调节 DNA 损伤反应中的 mRNA 剪接
CRISPR screening reveals ZNF217 as a vulnerability in high-risk B-cell acute lymphoblastic leukemia
CRISPR筛选揭示ZNF217是高危B细胞急性淋巴细胞白血病的一个脆弱点
FTO regulates ELK3-mediated metabolic rewiring and represents a unique therapeutic target in T cell leukemia
FTO调控ELK3介导的代谢重编程，是T细胞白血病中一个独特的治疗靶点。
Depletion of Fat Mass and Obesity-Associated Protein (FTO) Drives Heterochromatin Loss via Lysine Acetyltransferase 8 (KAT8)-Mediated Remodeling and Spacing Factor 1 (RSF1) Acetylation in Skin Aging.
脂肪量和肥胖相关蛋白 (FTO) 的消耗通过赖氨酸乙酰转移酶 8 (KAT8) 介导的重塑和间隔因子 1 (RSF1) 乙酰化驱动皮肤老化过程中的异染色质丢失
METTL16 Promotes Lipid Metabolic Reprogramming and Colorectal Cancer Progression.
METTL16促进脂质代谢重编程和结直肠癌进展
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