用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | Jurkat cells |
| Positive IHC detected in | mouse brain tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | mouse brain tissue, mouse embryo tissue |
| Positive IF-Fro detected in | mouse brain tissue |
| Positive IF/ICC detected in | HeLa cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Caspases, a family of endoproteases, are critical players in cell regulatory networks controlling inflammation and cell death. Initiator caspases (caspase-2, -8, -9, -10, -11, and -12) cleave and activate downstream effector caspases (caspase-3, -6, and -7), which in turn execute apoptosis by cleaving targeted cellular proteins. Caspase 3 plays a key role in the activation of sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase 3 can form heterocomplex with other proteins. This antibody can recognize the cleaved Caspase 3 fragments. This antibody is specific for cleaved caspase 3, and does not recognize full length caspase-3. The cleaved fragment of Caspase 3 might form complex and shows at around 30-35 kDa by western blot (PMID: 25501826).
文献引用 (62)
TRIM21-driven K63-linked ubiquitination of RBM38c, as a novel interactor of BECN1, contributes to DNA damage-induced autophagy.
TRIM21 驱动的 RBM38c 的 K63 连接的泛素化，作为 BECN1 的新型相互作用蛋白，促进 DNA 损伤诱导的自噬
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration.
分子伴侣介导的自噬指导双重机制，以平衡过早衰老和衰老细胞清除，从而防止椎间盘退变
In Situ Transformable Nanoparticle Effectively Suppresses Bladder Cancer by Damaging Mitochondria and Blocking Mitochondrial Autophagy Flux.
原位可转化纳米颗粒通过破坏线粒体和阻断线粒体自噬流有效抑制膀胱癌
Targeting CDK2 Confers Vulnerability to Lenvatinib Via Driving Senescence in Anaplastic Thyroid Cancer.
靶向 CDK2 通过驱动间变性甲状腺癌的衰老而使其对乐伐替尼产生易感性
Calcium dysregulation disrupts mitochondrial homeostasis by interfering AMPK/Drp1 pathway to aggravate plaque progression and instability
钙稳态失衡会干扰 AMPK/Drp1 通路，从而破坏线粒体稳态，加剧斑块进展和不稳定性。
Asparagine synthetase modulates glutaminase inhibitor sensitivity through metabolic reprogramming and serves as a prognostic biomarker in hepatocellular carcinoma.
天冬酰胺合成酶通过代谢重编程调节谷氨酰胺酶抑制剂的敏感性，并可作为肝细胞癌的预后生物标志物
Dietary cholesterol impairs cognition via gut microbiota-derived deoxycholic acid in obese mice.
膳食胆固醇通过肠道菌群衍生的脱氧胆酸损害肥胖小鼠的认知能力
Self-assembled genistein nanoparticles suppress the epithelial-mesenchymal transition in glioblastoma by targeting MMP9.
自组装染料木素纳米颗粒通过靶向 MMP9 抑制胶质母细胞瘤的上皮-间质转化
Heat acclimation mediates cellular protection via HSP70 stabilization of HIF-1α protein in extreme environments
热适应通过 HSP70 稳定 HIF-1α 蛋白来介导极端环境下的细胞保护
Tubular CD44 plays a key role in aggravating AKI through NF-κB p65-mediated mitochondrial dysfunction
管状 CD44 通过 NF-κB p65 介导的线粒体功能障碍在加重 AKI 中起关键作用
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