用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | U-251 cells, Raji cells, A549 cells, SH-SY5Y cells, MDA-MB-231 cells, PC-3 cells |
| Positive IHC detected in | human liver cancer tissue, human breast cancer tissue, human pancreas cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | L02 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Twist-related protein 1 (TWIST1), also named as BHLHA38, is 202 amino acid protein, which contains one bHLH domain. TWIST1 localizes in the nucleus and acts as a transcriptional regulator. TWIST1 inhibits monogenesis by sequestrating E proteins and inhibits tans-activation by MEF2. TWIST1 is expressed in subset of mesodermal cells. The antibody reacts specifically with Twist1 protein. The calculated molecular weight of TWIST1 is 21 kDa, but the observed molecular weight is about 30 kDa due to the post-translational modification(PMID: 30733340).
文献引用 (69)
Focal adhesion kinase/Src family kinase axis-mediated tyrosine phosphorylation of metabolic enzymes facilitates tumor metastasis
局灶性黏着斑激酶/Src家族激酶轴介导的代谢酶酪氨酸磷酸化促进肿瘤转移
GP73-dependent regulation of exosome biogenesis promotes colorectal cancer liver metastasis.
GP73依赖性外泌体生物发生调控促进结直肠癌肝转移
DSS1 inhibits autophagy to activate epithelial-mesenchymal transition in a pro-metastatic niche of renal cell carcinoma.
DSS1抑制自噬，从而激活肾细胞癌促转移微环境中的上皮-间质转化
Recapitulation of endochondral ossification by hPSC-derived SOX9+ sclerotomal progenitors
hPSC衍生的SOX9+硬节祖细胞重现软骨内成骨过程
Excessive MYC Orchestrates Macrophages induced Chromatin Remodeling to Sustain Micropapillary-Patterned Malignancy in Lung Adenocarcinoma.
MYC 过量调控巨噬细胞诱导的染色质重塑，以维持肺腺癌中的微乳头状恶性肿瘤
Exosomes of human adipose stem cells mitigate irradiation injury to salivary glands by inhibiting epithelial-mesenchymal transition through miR-199a-3p targeting Twist1 and regulating TGFβ1/Smad3 pathway
人脂肪干细胞外泌体通过miR-199a-3p靶向Twist1并调控TGFβ1/Smad3通路，抑制上皮-间质转化，从而减轻放射线对唾液腺的损伤。
Airway microbiota associated D-phenylalanine promotes non-small cell lung cancer metastasis through epithelial mesenchymal transition.
气道微生物群相关的D-苯丙氨酸通过上皮间质转化促进非小细胞肺癌转移
The cancer-associated fibroblasts interact with malignant T cells in mycosis fungoides and promote the disease progression
癌症相关成纤维细胞与蕈样肉芽肿中的恶性 T 细胞相互作用并促进疾病进展
CPT1A/HIF-1α positive feedback loop induced fatty acid oxidation metabolic pathway contributes to the L-ascorbic acid-driven angiogenesis in breast cancer.
CPT1A/HIF-1α正反馈环路诱导的脂肪酸氧化代谢途径促进了乳腺癌中L-抗坏血酸驱动的血管生成
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