CD63 Polyclonal antibody (25682-1-AP)
CD 63; CD63 antigen; Limp1; Lysosomal-associated membrane protein 3; Lysosome integral membrane protein 1
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | human urine exosomes tissue, A375 cells, human serum exosomes, THP-1 cells, human peripheral blood platelets |
| Positive IHC detected in | human malignant melanoma tissue, human lymphoma tissue, human tonsillitis tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | human malignant melanoma tissue |
| Positive IF/ICC detected in | A431 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
CD63 is a 30-60 kDa lysosomal membrane protein that belongs to the tetraspanin family. This protein plays many important roles in immuno-physiological functions. It mediates signal transduction events that play a role in the regulation of cell development, activation, growth, and motility. CD63 is expressed on activated platelets, thus it may function as a blood platelet activation marker. CD63 is a lysosomal membrane glycoprotein that is translocated to plasma membrane after platelet activation. The CD63 tetraspanin is highly expressed in the early stages of melanoma and decreases in advanced lesions, suggesting it as a possible suppressor of tumor progression. Deficiency of this protein is associated with Hermansky-Pudlak syndrome.
文献引用 (177)
Abnormal α-synuclein binds to synaptotagmin 13, impairing extracellular vesicle release in synucleinopathies.
异常的α-突触核蛋白与突触结合蛋白13结合，损害突触核蛋白病中的细胞外囊泡释放
Dysregulated mast cell activation induced by diabetic milieu exacerbates the progression of diabetic peripheral neuropathy in mice
糖尿病环境诱导的肥大细胞活化失调会加剧小鼠糖尿病周围神经病变的进展。
Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes
可注射的 ECM 模拟动态水凝胶通过递送髓核祖细胞衍生的外泌体来消除铁死亡诱导的椎间盘切除术后疝。
A glucose-enriched lung pre-metastatic niche triggered by matrix stiffness-tuned exosomal miRNAs in hepatocellular carcinoma
肝细胞癌中由基质硬度调控的外泌体miRNA触发的富含葡萄糖的肺转移前微环境
Harnessing macrophage-drug conjugates for allogeneic cell-based therapy of solid tumors via the TRAIN mechanism
利用巨噬细胞-药物偶联物通过TRAIN机制进行实体瘤的同种异体细胞治疗
Cardiac repair using regenerating neonatal heart tissue-derived extracellular vesicles
利用再生新生儿心脏组织来源的细胞外囊泡进行心脏修复
Comprehensive exome profiling identifies ARHGEF12 mutation as a driver in gastric cancer with ovarian metastasis.
全面的外显子组分析发现 ARHGEF12 突变是胃癌卵巢转移的驱动因素
DDX5 super-enhancer promotes vasculogenic mimicry formation and metastasis in nasopharyngeal carcinoma by enhancing ADAM10 transcription.
DDX5 超级增强子通过增强 ADAM10 转录促进鼻咽癌的血管生成拟态形成和转移
Sustained release of miR-21 carried by mesenchymal stem cell-derived exosomes from GelMA microspheres inhibits ovarian granulosa cell apoptosis in premature ovarian insufficiency.
GelMA微球中间充质干细胞来源的外泌体持续释放miR-21，可抑制卵巢早衰中卵巢颗粒细胞的凋亡
SESN2 inhibits tubular exosome secretion and diabetic kidney disease progression by restoring the autophagyâlysosome pathway.
SESN2 通过恢复自噬-溶酶体途径抑制肾小管外泌体分泌和糖尿病肾病进展
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