用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | rat brain tissue |
| Positive IP detected in | mouse brain tissue |
| Positive IHC detected in | mouse brain tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | mouse brain tissue |
| Positive IF-Fro detected in | rat brain tissue |
| Positive IF/ICC detected in | PC-12 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
TH(Tyrosine 3-monooxygenase) converts L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA), the essential and rate-limiting step to formation of dopamine and other catecholamines. TH plays an important role in the physiology of adrenergic neurons and can be used as a marker for dopaminergic and noradrenergic neurons. This protein has 6 isoforms produced by alternative splicing with the MW from 44 kDa to 58 kDa.
文献引用 (85)
The engineered probiotic strain Lactococcus lactis MG1363-pMG36e-GLP-1 regulates microglial polarization and gut dysbiosis in a transgenic mouse model of Parkinson's disease.
工程益生菌菌株乳酸乳球菌 MG1363-pMG36e-GLP-1 可调节帕金森病转基因小鼠模型中的小胶质细胞极化和肠道菌群失调
Chitosan alleviates symptoms of Parkinson's disease by reducing acetate levels, which decreases inflammation and promotes repair of the intestinal barrier and blood-brain barrier
壳聚糖通过降低醋酸盐水平来缓解帕金森病症状，从而减轻炎症并促进肠道屏障和血脑屏障的修复。
The ARC(CRABP1) neurons play a crucial role in the regulation of energy homeostasis.
ARC(CRABP1)神经元在能量稳态调节中起着至关重要的作用
Brown adipose tissue secretes OLFM4 to coordinate sensory and sympathetic innervation via Schwann cells
棕色脂肪组织分泌OLFM4，通过雪旺细胞协调感觉和交感神经支配。
PLK2 disrupts autophagic flux to promote SNCA/α-synuclein pathology
PLK2破坏自噬通量，促进SNCA/α-突触核蛋白病理的发生。
Neuronal FGF13 Inhibits Mitochondria-Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease.
神经元 FGF13 抑制线粒体衍生的损伤信号，从而预防帕金森病小鼠模型中的神经炎症和神经退行性变
Lamellar Schwann cells in the Pacinian corpuscle potentiate vibration perception.
帕西尼小体中的层状雪旺细胞增强振动感知
The selenocysteine-containing protein SELENOT maintains dopamine signaling in the midbrain to protect mice from hyperactivity disorder.
含硒半胱氨酸的蛋白质 SELENOT 维持中脑中的多巴胺信号传导，从而保护小鼠免受多动症的侵害
Urea cycle dysregulation drives metabolic stress and neurodegeneration in Parkinson's disease.
尿素循环失调是帕金森病中代谢压力和神经退行性变的主要驱动因素
Fibrinogen degradation products exacerbate alpha-synuclein aggregation by inhibiting autophagy via downregulation of Beclin1 in multiple system atrophy.
纤维蛋白原降解产物通过下调 Beclin1 抑制自噬，从而加剧多系统萎缩症中的 α-突触核蛋白聚集
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