Anti-Histone H3 (mono methyl K4) antibody - ChIP Grade (Ab8895)

H3FA, HIST1H3A, H3C2, H3FL, HIST1H3B, H3C3, H3FC HIST1H3C, H3C4, H3FB, HIST1H3D, H3C6, H3FD, HIST1H3E, H3C7, H3FI, HIST1H3F, H3C8, H3FH, HIST1H3G, H3C10, H3FK, HIST1H3H, H3C11, H3FF, HIST1H3I, H3C12, H3FJ, HIST1H3J, H3FC, HIST1H3C, H3C1, Histone H3.1, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, Histone H3/l, H3K4me, H3K4me1, H3K4

反应种属:Human, Mouse, Rat, Bovine
抗原名称:H3C1 mono methyl K4
应用:WB, IHC, IF/ICC, ChIP

详细信息

免疫原The exact immunogen used to generate this antibody is proprietary information.
宿主/亚型Rabbit / IgG
抗体类型Polyclonal
产品形式Liquid
纯化方式Affinity purification Immunogen
储存缓冲液pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
储存条件运输条件: Blue Ice 推荐的短期储存时间: 1-2 weeks 推荐的短期储存条件: +4°C 推荐的长期储存条件: -20°C 储存信息: Avoid freeze / thaw cycle

特异性

Specific for mono-methylated Lysine 4 of histone H3. Does not recognise di- or tri-methyl Lysine 4 nor methylation at Lysine 9.

背景信息

Anti-Histone H3 (mono methyl K4) antibody - ChIP Grade (ab8895) is a rabbit polyclonal antibody and is validated for use in ChIP, ICC/IF, IHC-P and WB. Anti-Histone H3 (mono methyl K4) antibody - ChIP Grade (ab8895) was first used in a scientific publication in 2003 and has been cited over 1122 times in peer reviewed journals. It's performance in ChIP in human, mouse and rat samples is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-Histone H3 (mono methyl K4) antibody - ChIP Grade (ab8895) has high sensitivity and specificity. Anti-Histone H3 (mono methyl K4) antibody - ChIP Grade (ab8895) has 58 independent reviews from customers. Anti-Histone H3 (mono methyl K4) antibody - ChIP Grade (ab8895) specifically detects Histone H3 Mono Methyl-K4 (UniProt ID: P68431; Molecular weight: 16kDa) and is sold in 50 µg selling sizes. Top cited antibody for this target with >1000 citations. A highly cited Histone H3 mono methyl K4 antibody, essential for studying epigenetic modifications and gene activation. This antibody is crucial in chromatin structure research, particularly in understanding the role of H3K4me1 in transcription regulation. It is widely used in as a marker for histone methylation and enhancer regions.

文献引用 (1139)

TGFβ induces an atypical EMT to evade immune mechanosurveillance in lung adenocarcinoma dormant metastasis.

TGFβ诱导非典型EMT以逃避肺腺癌休眠转移中的免疫机械监视。

Wang Zhenghan, Elbanna Yassmin, Godet Inês, Gan Siting, Peters Lila, Lampe George, Chen Yanyan, Xavier Joao, Huse Morgan, Massagué Joan

State-specific enhancer landscapes govern microglial plasticity.

特定状态的增强子图谱控制着小胶质细胞的可塑性。

Hamagami Nicole, Kapadia Dvita, Barclay Kia M, Huang Yanlong, Abduljawad Nora, Cheng Zuolin, McLaughlin Liam, Singhania Darsh, Ding Xukai, Yang Jin, Sun Zhixin, Karra Vikram, Du Siling, Bayguinov Peter, Yu Guoqiang, Li Yang E, Gabel Harrison W, Li Qingyun

Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation.

谱系决定性转录因子限制黏连蛋白,从而驱动多增强子癌基因调控。

Zhou Yeqiao, Jay Atishay, Burget Noah, Friedrich Tobias, Yoon Sora, Alsing Jessica, Nir Guy, Grosschedl Rudolf, Vahedi Golnaz, Faryabi Robert B

The Histone Methyltransferase KMT2D Is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration-Resistant Prostate Cancer.

组蛋白甲基转移酶 KMT2D 是去势抵抗性前列腺癌谱系可塑性和治疗反应的关键介质。

Kittane Srushti, Ladewig Erik, Li Taibo, Love Jillian R, Blawski Ryan, Gao Yangzhenyu, Arruabarrena-Aristorena Amaia, Zhao Peihua, Dalrymple Susan L, Liu Huayang, Guo Xinyu, Sallaku Mirna, Kelkar Nachiket, Garcia-Martinez Liliana, Carmona Sanz Javier, Chen Wanlu, Stoudmann Candice, Baldino Laura, Razavi-Mohseni Milad, Kalemi Ingrid, Beer Michael A, Castel Pau, Brennen W Nathaniel, Scaltriti Maurizio, Morey Lluis, Cocco Emiliano, Ji Hongkai, Chan Ho Man, Battle Alexis, Leslie Christina S, Karthaus Wouter R, Toska Eneda

Identification of cis-regulatory elements provides insights into tissue-specific gene regulation in the sheep genome.

顺式调控元件的鉴定有助于深入了解绵羊基因组中的组织特异性基因调控。

Xie Shangqian, Davenport Kimberly M, Salavati Mazdak, Caulton Alex, Clark Emily L, Archibald Alan L, Clarke Shannon M, Brauning Rudiger, Massa Alisha T, Mousel Michelle R, White Stephen N, Worley Kim C, Murdoch Gordon K, Becker Gabrielle, Stegmiller Morgan R, Khilji Sarem F, Shira Katie A, Olagunju Temitayo A, Hadfield Tracy, McKay Stephanie D, Rosen Benjamin D, Cockett Noelle E, Smith Timothy P L, Murdoch Brenda M

H3K4me1 directs H3K36me2 and H3K36me3 deposition in land plants.

H3K4me1 指导陆生植物中 H3K36me2 和 H3K36me3 的沉积。

Wu Jiabing, Wang Jiachen, Du Kangxi, Li Yingping, Xie Wenhao, He Chenxi, Xing Qidan, Li Xiang, Zhu Xiaoyu, Wu Zhen, Wu Xiaolong, Zhang Linghao, Shen Wen-Hui, Lan Fei, Gan Jianhua, Liu Bing, Dong Aiwu

Sequencing DNA methylation and hydroxymethylation at co-occurring chromatin features.

对共存染色质特征的 DNA 甲基化和羟甲基化进行测序。

Araujo Tavares Rafael de Cesaris, Dhir Somdutta, He Xuan, Monahan Jack, Taipale Minna, Golder Paula, Ciau-Uitz Aldo, Gosal Walraj, Tannahill David, Balasubramanian Shankar

AKAP95 condensates regulate transcription and can be targeted in MLL-fusion driven oncogenesis.

AKAP95 凝聚体调节转录,可作为 MLL 融合驱动的肿瘤发生的靶点。

Gut microbiota modulation of epigenetic target EHMT2: Lacticaseibacillus rhamnosus Fb7-311 regulated renal cell carcinoma apoptosis and metastasis.

肠道菌群对表观遗传靶标 EHMT2 的调控:鼠李糖乳杆菌 Fb7-311 调节肾细胞癌的凋亡和转移。

Lee Jeongmin, Lee Jinkwon, Tae In Hwan, Kang Yunsang, Kim Jinsan, Ryu Tae Young, Yang Haneol, Lee Su-Gi, Park Kunhyang, Park Doo-Sang, Jung Cho-Rok, Lim Jung Hwa, Lee Moo-Seung, Kim Dae-Soo, Son Mi-Young, Cho Hyun-Soo

A synergistic interaction between PRMT5 and LSD1 inhibitors in AML.

PRMT5 和 LSD1 抑制剂在急性髓系白血病中存在协同作用。

Param Nesteene Joy, Arceci Elisa, Fiorentino Francesco, Pignata Luca, Torre Denis, Gutiérrez-Trejo Nayeli, Fong Jia Yi, Goy Pierre-Alexis, Han Brenda Y, Lambona Chiara, Di Bello Elisabetta, Castiello Carola, Barone Marco, Schwarz Megan, Arrowsmith Cheryl, Ito Koichi, Scherle Peggy, Wee Dave Keng Boon, Ndoye Steven, Tabaglio Tommaso, Jeyasekharan Anand D, Lakshmanan Manikandan, Cirilli Roberto, Habisch Hansjörg, Madl Tobias, Mattevi Andrea, Valente Sergio, Mai Antonello, Guccione Ernesto
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