IL-1 beta Polyclonal antibody (16806-1-AP)
Catabolin; IL 1; IL 1 beta; IL1 beta; IL1- beta
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | LPS and Protein transport inhibitor treated THP-1 cells, human adrenal gland tissue, A431 cells |
| Positive IHC detected in | human tonsillitis tissue, human kidney tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | LPS treated THP-1 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Interleukin-1 is a pro-inflammatory cytokine with multiple biological effects. The IL-1 gene family encodes three proteins: IL-1α, IL-1β and their naturally occurring inhibitor Il-1RN. IL-1 Beta(IL-1β), mainly produced by blood monocytes and tissue macrophages, has been implicated in mediating both acute and chronic inflammation. IL-1β is known to be involved in a variety of cellular activities, including cell proliferation, differentiation and apoptosis. IL-1β is emerging as a key mediator of carcinogenesis that characterizes host-environment interactions. Human IL-1β is synthesized as a 31 kDa precursor. To gain activity, the precursor must be cleaved by caspase-1 between Asp116 and Ala117 to yield a 17 kDa mature form.
文献引用 (247)
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration.
分子伴侣介导的自噬指导双重机制，以平衡过早衰老和衰老细胞清除，从而防止椎间盘退变
Cell enlargement modulated by GATA4 and YAP instructs the senescence-associated secretory phenotype
GATA4 和 YAP 调控细胞增大，指导衰老相关的分泌表型
Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degeneration
分子伴侣介导的自噬对 PLCG1 的降解受损会促进细胞衰老和椎间盘退化
Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury.
普氏黄酮或其代谢产物脱氨基酪氨酸作为预防心肌缺血/再灌注损伤的药物
Absence of astrocytic ceruloplasmin reverses the senescence process with aging of learning and memory abilities.
星形胶质细胞铜蓝蛋白的缺失会逆转衰老过程中学习和记忆能力的衰退过程
ATP11B Modulates Microglial Lipid Metabolism and Alleviates Alzheimer's Disease Pathology.
ATP11B 调节小胶质细胞脂质代谢并缓解阿尔茨海默病病理
sLithospermic acid etched ZIF-8 nanoparticles delays osteoarthritis progression by inhibiting inflammatory signaling pathways and rescuing mitochondrial damage.
紫草酸蚀刻的 ZIF-8 纳米颗粒通过抑制炎症信号通路和修复线粒体损伤来延缓骨关节炎的进展
Thalidomide mitigates Crohn's disease colitis by modulating gut microbiota, metabolites, and regulatory T cell immunity.
沙利度胺通过调节肠道菌群、代谢物和调节性 T 细胞免疫来缓解克罗恩病结肠炎
Knockdown of PDPN in astrocytes reduces hippocampal inflammation in T2DM mice.
敲除星形胶质细胞中的 PDPN 可减轻 2 型糖尿病小鼠的海马炎症
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