用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | A549 cells, HeLa cells, Calu-1 cells, mouse brain tissue, rat brain tissue |
| Positive IP detected in | HeLa cells |
| Positive IHC detected in | human testis tissue, mouse testis tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | mouse testis tissue |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
ALKBH5, also named as ABH5 and OFOXD1, is a Dioxygenase that demethylates RNA by oxidative demethylation. It is a mammalian demethylase that oxidatively reverses m6A in mRNA in vitro and in vivo. ALKBH5 is required for spermatogenesis. There're some isoforms of ALKBH5 with MW 40-44 kDa and 52 kDa.
文献引用 (87)
FTO-associated osteoclastogenesis promotes alveolar bone resorption in apical periodontitis male rat via the HK1/USP14/RANK pathway
FTO 相关的破骨细胞生成通过 HK1/USP14/RANK 通路促进根尖周炎雄性大鼠的牙槽骨吸收。
Novel role of FTO in regulation of gut-brain communication via Desulfovibrio fairfieldensis-produced hydrogen sulfide under arsenic exposure
FTO 在砷暴露条件下通过脱硫弧菌 fairfieldensis 产生的硫化氢调节肠脑通讯的新作用
The dual mechanism of m(6)A demethylase ALKBH5 in regulating energy metabolism during exposure to MC-LR.
m(6)A 去甲基酶 ALKBH5 在暴露于 MC-LR 期间调节能量代谢的双重机制
YTHDF1 shapes immune-mediated hepatitis via regulating inflammatory cell recruitment and response.
YTHDF1 通过调节炎症细胞的募集和反应来影响免疫介导的肝炎
N6-methyladenosine Reader IGF2BP2-modified HMMR Promotes Non-small Cell Lung Cancer Metastasis via Interaction with MAP4K4
N6-甲基腺苷读取蛋白IGF2BP2修饰的HMMR通过与MAP4K4相互作用促进非小细胞肺癌转移
IGF2BP2 binding to CPSF6 facilitates m6A-mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer.
IGF2BP2 与 CPSF6 结合，促进 m6A 介导的 PUM2 的替代多聚腺苷酸化，并促进卵巢癌的恶性进展
RNA m6A involves in regulation of oxidative stress and apoptosis may via NF-kB pathway in cadmium-induced lung cells
RNA m6A 可能通过 NF-kB 通路参与调控镉诱导的肺细胞氧化应激和细胞凋亡
ALKBH5 regulates intrauterine adhesion progression through m6A dependent FABP4 mRNA stabilization and serum lipid metabolism.
ALKBH5 通过 m6A 依赖的 FABP4 mRNA 稳定和血清脂质代谢来调节宫内粘连的进展
Modification of RNF183 via m6A Methylation Mediates Podocyte Dysfunction in Diabetic Nephropathy by Regulating PKM2 Ubiquitination and Degradation
m6A甲基化修饰RNF183通过调节PKM2泛素化和降解介导糖尿病肾病中足细胞功能障碍
An Investigation of the RNA Modification m(6)A and Its Regulatory Enzymes in Rat Brains Affected by Chronic Morphine Treatment and Withdrawal.
对慢性吗啡治疗和戒断对大鼠脑内 RNA 修饰 m(6)A 及其调控酶的影响进行研究
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