Histone H3 Polyclonal antibody (17168-1-AP)
H3; HIST2H3A; H3C13; H3C14; H3C15
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HEK-293 cells, Hela cells, HepG cells, MCF-7 cells, NIH/3T3 cells, mouse kidney tissue, rat kidney tissue |
| Positive IP detected in | MCF-7 cells |
| Positive IHC detected in | human oesophagus cancer tissue, human skin cancer tissue, human breast cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | HeLa cells |
| Positive FC (Intra) detected in | HeLa cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Histone-H3, histone cluster 2, H3a is the core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machinery which requires DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histone-H3 is expressed during S phase; then expression strongly decreases as cell division slows down during the process of differentiation.
文献引用 (436)
Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness
肠道菌群失调通过传递心理压力激活LRP5/β-catenin通路，从而促进癌症干性。
NNMT promotes acquired EGFR-TKI resistance by forming EGR1 and lactate-mediated double positive feedback loops in non-small cell lung cancer.
NNMT 通过在非小细胞肺癌中形成 EGR1 和乳酸介导的双重正反馈环路来促进获得性 EGFR-TKI 耐药性
Mono-ubiquitination of TopBP1 by PHRF1 enhances ATR activation and genomic stability
PHRF1 对 TopBP1 的单泛素化增强了 ATR 活化和基因组稳定性
Mechanism of ASF1 engagement by CDAN1.
CDAN1 介导 ASF1 结合的机制
The Trim32-DPEP2 axis is an inflammatory switch in macrophages during intestinal inflammation.
Trim32-DPEP2 轴是肠道炎症期间巨噬细胞中的炎症开关
hnRNPL phase separation activates PIK3CB transcription and promotes glycolysis in ovarian cancer
hnRNPL相分离激活PIK3CB转录并促进卵巢癌中的糖酵解
MARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA
MARTRE 家族蛋白负向调控 CCR4-NOT 活性以保护 poly(A) 尾长度并促进母体 mRNA 的翻译
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway
游离脂肪酸受体-4通过激活芳烃受体通路调节T细胞介导的同种异体反应。
A glucose-enriched lung pre-metastatic niche triggered by matrix stiffness-tuned exosomal miRNAs in hepatocellular carcinoma
肝细胞癌中由基质硬度调控的外泌体miRNA触发的富含葡萄糖的肺转移前微环境
GRK2 activates TRAF2-NF-κB signalling to promote hyperproliferation of fibroblast-like synoviocytes in rheumatoid arthritis.
GRK2 激活 TRAF2-NF-κB 信号通路，促进类风湿性关节炎中成纤维细胞样滑膜细胞的过度增殖
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