Anti-Histone H3 (tri methyl K9) antibody - ChIP Grade (Ab8898)
H3FA, HIST1H3A, H3C2, H3FL, HIST1H3B, H3C3, H3FC HIST1H3C, H3C4, H3FB, HIST1H3D, H3C6, H3FD, HIST1H3E, H3C7, H3FI, HIST1H3F, H3C8, H3FH, HIST1H3G, H3C10, H3FK, HIST1H3H, H3C11, H3FF, HIST1H3I, H3C12, H3FJ, HIST1H3J, H3C1, H3FC, HIST1H3C, Histone H3.1, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, Histone H3/l, H3K9me3, H3K9me, H3K9
详细信息
特异性
Histone H3 (tri methyl K9) antibody (ab8898) is specific for Histone H3 tri methyl Lysine 9. Shows slight cross-reactivity with tri methyl K27, which shares a similar epitope (please see Western blot image). Does not react with mono or di methylated K9. From Jan 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help. You may also be interested in our alternative recombinant antibody, ab176916.
背景信息
Anti-Histone H3 (tri methyl K9) antibody - ChIP Grade (ab8898) is a rabbit polyclonal antibody and is validated for use in ChIP, ICC/IF, IHC-P and WB. Anti-Histone H3 (tri methyl K9) antibody - ChIP Grade (ab8898) was first used in a scientific publication in 2003 and has been cited over 1737 times in peer reviewed journals. It's performance in ChIP, Western Blot, IHC in human, mouse and rat samples is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-Histone H3 (tri methyl K9) antibody - ChIP Grade (ab8898) has high sensitivity and specificity. Anti-Histone H3 (tri methyl K9) antibody - ChIP Grade (ab8898) has 91 independent reviews from customers. Anti-Histone H3 (tri methyl K9) antibody - ChIP Grade (ab8898) specifically detects Histone H3 Tri Methyl-K9 (UniProt ID: P68431; Molecular weight: 16kDa) and is sold in 100 µg selling sizes. Top cited antibody for this target with >2000 citations and >60 five star abreviews. Key target to study histone H3 trimethylation, epigenetic regulation and chromatin structure. This antibody is crucial in cancer research, particularly in understanding H3K9me3's role in gene silencing and heterochromatin formation and is widely used in studies of transcriptional repression and histone modifications involving histone methyltransferases. Key histone marker that has been implicated in both transcriptional activation and silencing.
文献引用 (1843)
NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers.
NSD2抑制剂通过重塑染色质来治疗肺癌和胰腺癌。
CRISPR screen of human pancreatic cancer xenografts identifies a KLF5 proliferation vulnerability through epigenetic modifiers NCAPD2 and MTHFD1.
通过 CRISPR 筛选人类胰腺癌异种移植瘤，发现 KLF5 增殖脆弱性与表观遗传修饰因子 NCAPD2 和 MTHFD1 有关。
CBFA2T2: a novel H3K27 reader regulating metabolism and tumor growth.
CBFA2T2：一种新型的 H3K27 阅读器，可调节代谢和肿瘤生长。
Transient histone deacetylase inhibition induces cellular memory of gene expression and 3D genome folding.
瞬时组蛋白去乙酰化酶抑制可诱导细胞对基因表达和 3D 基因组折叠的记忆。
Cell cycle arrest enhances CD8(+) T cell effector function by potentiating glucose metabolism and IL-2 signaling.
细胞周期阻滞通过增强葡萄糖代谢和IL-2信号传导来增强CD8(+) T细胞效应功能。
Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming.
层粘蛋白 A/C 调控的半胱氨酸分解代谢通量通过表观基因组重编程调节干细胞命运。
ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei.
内质网锚定引导 TREX1 穿透微核处 BAF 依赖性屏障。
Transcriptional competence defines the heterochromatin nucleating potential of isolated MSR units.
转录能力决定了分离的 MSR 单元的异染色质成核潜力。
Improving erectile function in diabetic male mice by rescuing depalmitoylated FBP1 to reduce cavernosal lactate.
通过挽救去棕榈酰化的 FBP1 来降低海绵体乳酸水平，从而改善糖尿病雄性小鼠的勃起功能。
Counteracting FOX proteins epigenetically control the herpesvirus lytic-latent balance.
通过表观遗传学手段对抗 FOX 蛋白，从而控制疱疹病毒的裂解-潜伏平衡。
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