MMP13 Polyclonal antibody (18165-1-AP)
CLG3; Collagenase 3; EC:3.4.24.-; Matrix metalloproteinase 13; Matrix metalloproteinase-13
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HeLa cells, MCF-7 cells, MDA-MB-453s cells, mouse liver tissue, rat liver tissue, HepG2 cells |
| Positive IP detected in | MCF-7 cells |
| Positive IHC detected in | human liver tissue, human hepatocirrhosis tissue, mouse liver tissue, human liver cancer tissue, human breast cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | MCF-7 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
MMP-13(Matrix metalloproteinase-13), cleaves type I collagen and was previously thought to be the rodent analogue of human interstitial MMP-1. MMP-13 is found in hypertrophic and calcifying cartilage of mammalian growth plate. The bands seen with rat MMP-13 are consistent with a 59-kDa latent form and a 43-kDa active form reported for this enzyme, along with a smaller band at approximately 30 kDa(PMID:10771523). It also can be detected 3 bands that the glycosylated proMMP-13 (70 kDa), unglycosylated proform (55 kDa), and active MMP-13 enzyme (40kDa) by western blot(PMID:18332263).
文献引用 (213)
Streamlined metal-based hydrogel facilitates stem cell differentiation, extracellular matrix homeostasis and cartilage repair in male rats.
流线型金属基水凝胶可促进雄性大鼠干细胞分化、细胞外基质稳态和软骨修复
Targeted Blockage of Pathological Extracellular Vesicles and Particles From Fibroblast-Like Synoviocytes for Osteoarthritis Relief: Proteomic Analysis and Cellular Effect
靶向阻断成纤维细胞样滑膜细胞释放的病理性细胞外囊泡和颗粒以缓解骨关节炎：蛋白质组学分析和细胞效应
Osteocyte-derived extracellular vesicles mediate the bone-to-cartilage crosstalk and promote osteoarthritis progression
骨细胞来源的细胞外囊泡介导骨与软骨之间的相互作用，并促进骨关节炎的进展。
USP5-Rich Apoptotic Extracellular Vesicles Regulate Nucleus Pulposus Cells Apoptosis and DNA Damage Repair by Preventing E2F1 Proteasomal Degradation.
富含 USP5 的凋亡细胞外囊泡通过阻止 E2F1 蛋白酶体降解来调节髓核细胞凋亡和 DNA 损伤修复
Tree shrew as a new animal model for musculoskeletal disorders and aging
树鼩作为肌肉骨骼疾病和衰老的新动物模型
LIPUS Promotes Calcium Oscillation and Enhances Calcium Dependent Autophagy of Chondrocytes to Alleviate Osteoarthritis.
LIPUS促进钙振荡并增强软骨细胞的钙依赖性自噬，从而缓解骨关节炎
Eosinophils-Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF-β Pathway Mediated by Anxa1 Binding.
嗜酸性粒细胞诱导滑膜成纤维细胞分泌 Lumican，通过 Anxa1 结合介导的 TGF-β 通路缓解软骨退化
β-Mangostin Attenuates TET2-Mediated DNA Demethylation of Prkcg in the Prevention of Intervertebral Disc Degeneration.
β-倒捻子素减弱TET2介导的Prkcg DNA去甲基化，从而预防椎间盘退变
UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling.
UGDH 乳酸化通过抑制糖胺聚糖合成和协调核质运输激活 MAPK 信号传导来加剧骨关节炎
Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1.
人参三醇通过靶向 UFL1 发挥抗衰老作用，缓解骨关节炎和软骨修复纤维化
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