VEGFA Polyclonal antibody (19003-1-AP)
VEGF; L-VEGF; N-VEGF; Vascular Endothelial Growth Factor; vascular endothelial growth factor A
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | A431 cells, bEnd.3 cells, C6 cells, Jurkat cells, MCF-7 cells |
| Positive IP detected in | Jurkat cells |
| Positive IHC detected in | human lung cancer tissue, human liver cancer tissue, mouse kidney tissue, mouse liver tissue, mouse lung tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | human liver cancer tissue |
| Positive IF/ICC detected in | HeLa cells, MCF-7 cells, NIH/3T3 cells |
| Positive FC (Intra) detected in | NIH/3T3 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
VEGFA, also named VEGF or VPF, belongs to the PDGF/VEGF growth factor family. It is a growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. VEGFA induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Defects in VEGFA are associated with microvascular complications of diabetes type 1 (MVCD1). VEGFA has 17 isoforms with MW from 16 to 45 kDa. Some isoforms have homodimer forms (e.g.; VEGFA189 38 kDa or VEFGA110 34 kDa). VEGF-A exists in at least seven homodimeric isoforms. The monomers consist of 121, 145, 148, 165, 183, 189, or 206 amino acids (PMID:15602010 ). This antibody can recognize all VEGFA isoforms.
文献引用 (289)
Identifying fibroblast-derived sFRP2 as a therapeutic target and engineering siRNA therapy for uterine scarring.
确定成纤维细胞衍生的 sFRP2 作为治疗靶点，并设计 siRNA 疗法治疗子宫瘢痕
Endothelial AGGF1 promotes retinal angiogenesis by coordinating TNFSF12/FN14 signalling
内皮细胞 AGGF1 通过协调 TNFSF12/FN14 信号传导促进视网膜血管生成
Atractylenolide I inhibits angiogenesis and reverses sunitinib resistance in clear cell renal cell carcinoma through ATP6V0D2-mediated autophagic degradation of EPAS1/HIF2α
白术内酯 I 通过 ATP6V0D2 介导的 EPAS1/HIF2α 自噬降解抑制血管生成并逆转透明细胞肾细胞癌的舒尼替尼耐药性
Injectable pH Responsive Conductive Hydrogel for Intelligent Delivery of Metformin and Exosomes to Enhance Cardiac Repair after Myocardial Ischemia-Reperfusion Injury.
可注射的 pH 响应导电水凝胶，用于智能递送二甲双胍和外泌体，以增强心肌缺血再灌注损伤后的心脏修复
Delivery of an ERK inhibitor using bioactive lipid nanoparticles reduces angiogenesis and prevents oral squamous cell carcinoma development.
利用生物活性脂质纳米颗粒递送 ERK 抑制剂可减少血管生成并预防口腔鳞状细胞癌的发生
Nanosilicates promote angiogenesis through activation of ROS-mediated WNT/β-catenin pathway.
纳米硅酸盐通过激活 ROS 介导的 WNT/β-catenin 通路促进血管生成
Injectable deferoxamine-loaded microsphere hydrogels for inhibition of ferroptosis and promotion of third-degree burn wound healing.
可注射的载有去铁胺的微球水凝胶，用于抑制铁死亡和促进三度烧伤创面愈合
Dominant follicle-targeted nanocarriers for GH delivery to alleviate premature ovarian insufficiency.
以优势卵泡为靶点的纳米载体用于输送生长激素，以缓解卵巢早衰
A novel therapeutic approach to hemangiomas: Combining photothermal therapy and ferroptosis in a microneedle delivery system.
治疗血管瘤的新方法：将光热疗法和铁死亡疗法结合在微针输送系统中
Thermosensitive hydrogel composite with si-Cx43 nanoparticles and anti-VEGF agent for synergistic treatment of diabetic retinopathy.
含有si-Cx43纳米颗粒和抗VEGF剂的热敏水凝胶复合材料，用于协同治疗糖尿病视网膜病变
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