用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | MOLT-4 cells, human peripheral blood leukocyte |
| Positive IHC detected in | human tonsillitis tissue, human appendicitis tissue, human breast cancer tissue, human colon cancer tissue, human lung cancer tissue, human pancreas cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | human tonsillitis tissue |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
CD8 is a transmembrane glycoprotein that is predominantly expressed on the surface of cytotoxic T cells, and can also be found on natural killer cells, cortical thymocytes, and dendritic cells. CD8 serves as a co-receptor for the T cell receptor (TCR). Both CD8 and TCR recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. CD8 plays a role in T cell development and activation of mature T cells. This antibody is raised against 23-183 aa of human CD8a, the alpha chain of CD8 molecule.
文献引用 (84)
MIAT promotes tumor-infiltrating CD8(+) T-cell exhaustion and malignant progression of renal cell carcinoma via activating JAK3/STAT3 pathway.
MIAT 通过激活 JAK3/STAT3 通路促进肿瘤浸润 CD8(+) T 细胞耗竭和肾细胞癌的恶性进展
Ultrasound-Targeted Nanobubbles Codelivering NKP-1339 and miR-142-5p for Synergistic Mitochondrial Immunogenic Cell Death and PD-L1 Inhibition in Cancer Therapy.
超声靶向纳米气泡共递送 NKP-1339 和 miR-142-5p，用于协同诱导线粒体免疫原性细胞死亡和抑制 PD-L1 以治疗癌症
Simvastatin inhibits PD-L1 via ILF3 to induce ferroptosis in gastric cancer cells.
辛伐他汀通过ILF3抑制PD-L1，从而诱导胃癌细胞发生铁死亡
Cholesterol biosynthesis induced by radiotherapy inhibits cGAS-STING activation and contributes to colorectal cancer treatment resistance
放射疗法诱导的胆固醇生物合成会抑制cGAS-STING的激活，从而导致结直肠癌治疗耐药。
Single-cell Profiling of Intrahepatic Immune Cells Reveals an Expansion of Tissue-resident Cytotoxic CD4+ T Lymphocyte Subset Associated With Pathogenesis of Alcoholic-associated Liver Diseases
肝内免疫细胞的单细胞分析揭示了组织驻留细胞毒性 CD4+ T 淋巴细胞亚群的扩增与酒精性肝病的发病机制有关
Single-cell transcriptomic analysis of the senescent microenvironment in bone metastasis
骨转移中衰老微环境的单细胞转录组分析
NALCN expression is down-regulated and associated with immune infiltration in gastric cancer
NALCN表达下调，且与胃癌中的免疫浸润相关。
Histone deacetylases 10 as a prognostic biomarker correlates with tumor microenvironment and therapy response in colorectal cancer.
组蛋白去乙酰化酶 10 作为预后生物标志物与结直肠癌的肿瘤微环境和治疗反应相关
Spautin-1 inhibits the growth of diffuse large B-cell lymphoma by inducing mitochondrial damage-mediated PANoptosis and anti-tumor immunity.
Spautin-1 通过诱导线粒体损伤介导的 PANoptosis 和抗肿瘤免疫来抑制弥漫性大 B 细胞淋巴瘤的生长
Machine learning-based integration develops a hypoxia-derived signature for improving outcomes in glioma.
基于机器学习的集成开发出一种缺氧衍生特征，用于改善胶质瘤的治疗效果
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