Phospho-mTOR (Ser2448) Monoclonal antibody (67778-1-Ig)
mTOR (Ser2448); p mTOR; p mTOR (Ser2448); p mTOR Ser2448; Phospho mTOR
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HeLa cells, NIH/3T3 cells, HEK-293T cells, HEK-293 cells, HSC-T6 cells, Calyculin A treated HeLa cells, EGF treated NIH/3T3 cells, Rapamycin treated HEK-293 cells, Calyculin A treated HEK-293 cells |
| Positive IF/ICC detected in | HepG2 cells |
| Positive FC (Intra) detected in | Calyculin A treated HeLa cells, 100 nM Calyculin A (30 minutes) treated HeLa cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
MTOR, also named as FRAP1, FRAP, FRAP2 and RAPT1, belongs to the PI3/PI4-kinase family. MTOR is a Ser/Thr protein kinase that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth. MTOR is kinase subunit of both mTORC1 and mTORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTOR is phosphorylated at Ser2448 via the PI3 kinase/Akt signaling pathway and autophosphorylated at Ser2481. mTOR plays a key role in cell growth and homeostasis and may be abnormally regulated in tumors.
文献引用 (136)
USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer.
USP19 通过去泛素化 NEK9 抑制 mTOR 通路，从而增强胰腺癌细胞的自噬性细胞死亡
Natural Enzyme-Loaded Polymeric Stealth Coating-Armed Engineered Probiotics by Disrupting Tumor Lactate Homeostasis to Synergistic Metabolism-Immuno-Enzyme Dynamic Therapy.
通过破坏肿瘤乳酸稳态，利用天然酶负载聚合物隐形涂层武装工程益生菌，实现代谢-免疫-酶动态协同疗法
Inhibition of Aberrant Activated Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism.
利什曼原虫肽通过调节脂肪酸合成代谢抑制类风湿性关节炎中异常活化的成纤维细胞样滑膜细胞
Targeting PSMD14 combined with arachidonic acid induces synthetic lethality via FADS1 m6A modification in triple-negative breast cancer
靶向PSMD14联合花生四烯酸可通过FADS1 m6A修饰诱导三阴性乳腺癌的合成致死效应
Carbon dot-based treatment for bacterial pneumonia by promoting a PI3K-mediated M1 polarization of macrophages
通过促进巨噬细胞PI3K介导的M1极化，利用碳点治疗细菌性肺炎
TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis
TREM2通过调节小胶质细胞糖酵解影响小鼠TBI急性期DAM样细胞转化
Cancer-associated Fibroblast-like Cells Promote Osteosarcoma Metastasis by Upregulation of Phosphoserine Aminotransferase 1 and Activation of the mTOR/S6K Pathway
癌症相关成纤维细胞样细胞通过上调磷酸丝氨酸氨基转移酶1和激活mTOR/S6K通路促进骨肉瘤转移
hUC-MSCs and derived exosomes attenuate DEX-induced muscle atrophy through modulation of estrogen signaling pathway.
hUC-MSCs及其衍生的外泌体通过调节雌激素信号通路来减轻DEX诱导的肌肉萎缩
CENPF interaction with PLA2G4A promotes glioma growth by modulating mTORC1 and NF-κB pathways.
CENPF 与 PLA2G4A 的相互作用通过调节 mTORC1 和 NF-κB 通路促进胶质瘤生长
Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression.
α-突触核蛋白原纤维抑制mPFC中BDNF/ERK信号环的激活，从而诱发帕金森病样改变并伴有抑郁症
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