Bcl2 Monoclonal antibody (68103-1-Ig)
Bcl-2; B cell leukemia/lymphoma 2; Bcl 2
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HSC-T6 cells, C2C12 cells, NIH/3T3 cells, mouse spleen tissue, mouse brain tissue, rat spleen tissue, RAW 264.7 cells, rat brain tissue |
| Positive IHC detected in | mouse kidney tissue, rat skin tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | NIH/3T3 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Bcl2 is a member of the B cell lymphoma 2 protein family. Members of this family regulate cell death in multiple cell types and can have either proapoptotic or antiapoptotic activities. The protein encoded by this gene inhibits mitochondrial-mediated apoptosis. This protein is an integral outer mitochondrial membrane protein that functions as part of signaling pathway that controls mitochondrial permeability in response to apoptotic stimuli. This protein may also play a role in neuron cell survival and autophagy. Abnormal expression and chromosomal translocations of this gene are associated with cancer progression in numerous tissues.
文献引用 (104)
Injectable pH Responsive Conductive Hydrogel for Intelligent Delivery of Metformin and Exosomes to Enhance Cardiac Repair after Myocardial Ischemia-Reperfusion Injury.
可注射的 pH 响应导电水凝胶，用于智能递送二甲双胍和外泌体，以增强心肌缺血再灌注损伤后的心脏修复
Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization.
异槲皮苷通过抑制 STAT3 磷酸化和二聚化来缓解糖尿病肾病
A Dual Approach with Organoid and CRISPR Screening Reveals ERCC6 as a Determinant of Cisplatin Resistance in Osteosarcoma.
采用类器官和 CRISPR 筛选的双重方法揭示 ERCC6 是骨肉瘤顺铂耐药性的决定因素
UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling.
UGDH 乳酸化通过抑制糖胺聚糖合成和协调核质运输激活 MAPK 信号传导来加剧骨关节炎
Early assessment and treatment of ventricular remodeling in vivo via a targeted ultrasonic molecular probe loaded with oxygen and cholecystokinin.
利用载有氧气和胆囊收缩素的靶向超声分子探针，对体内心室重构进行早期评估和治疗
A dual-targeting bio-liposomes nanodrug repair endothelial cell dysfunction and restore macrophage cholesterol flow homeostasis to treat early atherosclerosis.
双靶向生物脂质体纳米药物修复内皮细胞功能障碍并恢复巨噬细胞胆固醇流动稳态，以治疗早期动脉粥样硬化
Mitochondrial homeostasis restoring peptide-drug conjugates with ROS-responsive NO releasing ability for targeted therapy of myocardial infarction.
具有 ROS 响应性 NO 释放能力的线粒体稳态恢复肽-药物偶联物，用于心肌梗死的靶向治疗
Application of PVA hydrogel loaded with luteolin nanoparticles in anti EMT treatment after GBM.
将载有木犀草素纳米粒子的聚乙烯醇水凝胶应用于胶质母细胞瘤抗EMT治疗
Self-assembled genistein nanoparticles suppress the epithelial-mesenchymal transition in glioblastoma by targeting MMP9.
自组装染料木素纳米颗粒通过靶向 MMP9 抑制胶质母细胞瘤的上皮-间质转化
FNDC5/Irisin exacerbates APAP-induced acute liver injury through activating JNK/NF-κB and inflammatory response.
FNDC5/Irisin 通过激活 JNK/NF-κB 和炎症反应加剧 APAP 引起的急性肝损伤
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