用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | A549 cells, MDA-MB-231 cells, Caco-2 cells, HEK-293 cells, HeLa cells, HEK-293T cells, SH-SY5Y cells |
| Positive IHC detected in | human liver cancer tissue, human breast cancer tissue, human colon tissue, human stomach cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | human lymphoma tissue, human liver cancer tissue |
| Positive FC (Intra) detected in | SH-SY5Y cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Fat mass and obesity-associated protein (FTO) has efficient oxidative demethylation activity targeting the abundant N6-methyladenosine (m6A) residues in RNA in vitro. Variants in the FTO (fat mass and obesity associated) gene are associated with increased body mass index in humans.
文献引用 (95)
FTO-associated osteoclastogenesis promotes alveolar bone resorption in apical periodontitis male rat via the HK1/USP14/RANK pathway
FTO 相关的破骨细胞生成通过 HK1/USP14/RANK 通路促进根尖周炎雄性大鼠的牙槽骨吸收。
Nuclear accumulation of YTHDF1 regulates mRNA splicing in the DNA damage response.
YTHDF1 的核内积累调节 DNA 损伤反应中的 mRNA 剪接
Novel role of FTO in regulation of gut-brain communication via Desulfovibrio fairfieldensis-produced hydrogen sulfide under arsenic exposure
FTO 在砷暴露条件下通过脱硫弧菌 fairfieldensis 产生的硫化氢调节肠脑通讯的新作用
FTO regulates ELK3-mediated metabolic rewiring and represents a unique therapeutic target in T cell leukemia
FTO调控ELK3介导的代谢重编程，是T细胞白血病中一个独特的治疗靶点。
YTHDF1 shapes immune-mediated hepatitis via regulating inflammatory cell recruitment and response.
YTHDF1 通过调节炎症细胞的募集和反应来影响免疫介导的肝炎
SARS-CoV-2 and HCoV-OC43 regulate host m6A modification via activation of the mTORC1 signalling pathway to facilitate viral replication
SARS-CoV-2 和 HCoV-OC43 通过激活 mTORC1 信号通路来调节宿主 m6A 修饰，以促进病毒复制
m6A reader IGF2BP2-stabilized lncRNA LHX1-DT inhibits renal cell carcinoma (RCC) cell proliferation and invasion by sponging miR-590-5p.
m6A 阅读器 IGF2BP2 稳定的 lncRNA LHX1-DT 通过海绵吸附 miR-590-5p 来抑制肾细胞癌 (RCC) 细胞的增殖和侵袭
Exosome-derived long non-coding RNA AC010789.1 modified by FTO and hnRNPA2B1 accelerates growth of hair follicle stem cells against androgen alopecia by activating S100A8/Wnt/β-catenin signalling
外泌体来源的长链非编码RNA AC010789.1经FTO和hnRNPA2B1修饰后，通过激活S100A8/Wnt/β-catenin信号通路，加速毛囊干细胞生长，对抗雄激素性脱发。
FTO-mediated m(6)A demethylation regulates IGFBP3 expression and AKT activation through IMP3-dependent P-body re-localisation in lung cancer.
FTO 介导的 m(6)A 去甲基化通过 IMP3 依赖的 P 小体重新定位来调节肺癌中的 IGFBP3 表达和 AKT 激活
Genome-wide profiling of N6-methyladenosine-modified pseudogene-derived long noncoding RNAs reveals the tumour-promoting and innate immune-restraining function of RPS15AP12 in ovarian cancer.
对 N6-甲基腺苷修饰的假基因衍生的长链非编码 RNA 进行全基因组分析，揭示了 RPS15AP12 在卵巢癌中的促肿瘤和先天免疫抑制功能
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