用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive IHC detected in | human tonsillitis tissue, human colon cancer tissue, human gliomas tissue, human lung cancer tissue, human skin cancer tissue, human lymphoma tissue, human breast cancer tissue, Insulinoma tissue, K-562 cells Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | human tonsillitis tissue, human lung cancer tissue |
| Positive IF/ICC detected in | HeLa cells, HEK-293 cells |
| Positive FC (Intra) detected in | Jurkat cells |
推荐稀释比例
- Immunohistochemistry (IHC)1:4000-1:16000
- Immunofluorescence (IF)-P1:200-1:800
- Immunofluorescence (IF)/ICC1:50-1:500
- Flow Cytometry (FC) (INTRA)0.40 ug per 10^6 cells in a 100 µl suspension
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
The Ki-67 protein (also known as MKI67) is a cellular marker for proliferation. Ki67 is present during all active phases of the cell cycle (G1, S, G2 and M), but is absent in resting cells (G0). Cellular content of Ki-67 protein markedly increases during cell progression through S phase of the cell cycle. Therefore, the nuclear expression of Ki67 can be evaluated to assess tumor proliferation by immunohistochemistry. It has been demonstrated to be of prognostic value in breast cancer. In head and neck cancer, several studies have reported an association between high proliferative activity and poorer prognosis.
文献引用 (516)
Inhibition of 6-phosphogluconate dehydrogenase suppresses esophageal squamous cell carcinoma growth and enhances the anti-tumor effects of metformin via the AMPK/mTOR pathway.
抑制 6-磷酸葡萄糖酸脱氢酶可抑制食管鳞状细胞癌的生长，并通过 AMPK/mTOR 通路增强二甲双胍的抗肿瘤作用
GP73-dependent regulation of exosome biogenesis promotes colorectal cancer liver metastasis.
GP73依赖性外泌体生物发生调控促进结直肠癌肝转移
Cytosolic Phospholipase A2 Determines Intercellular Heterogeneity of Stress Granules and Chemotherapy Response
胞质磷脂酶A2决定应激颗粒的细胞间异质性和化疗反应
Identifying fibroblast-derived sFRP2 as a therapeutic target and engineering siRNA therapy for uterine scarring.
确定成纤维细胞衍生的 sFRP2 作为治疗靶点，并设计 siRNA 疗法治疗子宫瘢痕
Responsive DNA artificial cells for contact and behavior regulation of mammalian cells.
用于调控哺乳动物细胞接触和行为的响应型DNA人工细胞
OFD1 inhibition induces BRCAness to create a therapeutic vulnerability to PARP inhibition in pancreatic cancer.
OFD1 抑制诱导 BRCA 样改变，从而使胰腺癌对 PARP 抑制剂产生治疗敏感性
USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer.
USP19 通过去泛素化 NEK9 抑制 mTOR 通路，从而增强胰腺癌细胞的自噬性细胞死亡
AKAP1/PKA-mediated GRP75 phosphorylation at mitochondria-associated endoplasmic reticulum membranes protects cancer cells against ferroptosis.
AKAP1/PKA介导的GRP75在与线粒体相关的内质网膜上的磷酸化可保护癌细胞免受铁死亡的影响
Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity
衰老调节性T细胞中SOAT2表达增加与胆固醇代谢改变和抗肿瘤免疫力下降有关。
Hypoxia-induced BNIP3 facilitates the progression and metastasis of uveal melanoma by driving metabolic reprogramming.
缺氧诱导的 BNIP3 通过驱动代谢重编程促进葡萄膜黑色素瘤的进展和转移
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