用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive IHC detected in | human colon tissue, human pancreas cancer tissue, mouse small intestine tissue, rat small intestine tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | human colon tissue, mouse colon tissue, rat small intestine tissue |
| Positive IF/ICC detected in | HepG2 cells, SW480 cells |
| Positive FC (Intra) detected in | MCF-7 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis.
文献引用 (41)
Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice
雄性小鼠小肠γδ T17细胞通过STING/C1q诱导的小胶质细胞突触修剪促进SAE
Novel role of FTO in regulation of gut-brain communication via Desulfovibrio fairfieldensis-produced hydrogen sulfide under arsenic exposure
FTO 在砷暴露条件下通过脱硫弧菌 fairfieldensis 产生的硫化氢调节肠脑通讯的新作用
Luteolin improves precancerous conditions of the gastric mucosa by binding STAT3 and inhibiting LCN2 expression.
木犀草素通过与 STAT3 结合并抑制 LCN2 表达来改善胃黏膜癌前状况
Banxia Xiexin Decoction inhibits colitis-associated colorectal cancer development by modulating STAT3 signaling and gut microbiota.
半夏泻心汤通过调节 STAT3 信号和肠道菌群抑制结肠炎相关结直肠癌的发展
Dietary iron attenuates Clostridioides difficile infection via modulation of intestinal immune response and gut microbiota
膳食铁通过调节肠道免疫反应和肠道菌群来减轻艰难梭菌感染。
Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation.
润昌宁神膏激活 NLRP6 炎症小体介导的自噬，刺激结肠粘蛋白-2 分泌，调节功能性便秘中的粘膜微生物群
Agrocybe cylindracea Polysaccharides Ameliorate DSS-Induced Colitis by Restoring Intestinal Barrier Function and Reprogramming Immune Homeostasis via the Gut-Liver Axis.
圆筒菌多糖通过恢复肠道屏障功能和通过肠-肝轴重编程免疫稳态来改善DSS诱导的结肠炎
Neohesperidin Mitigates High-Fat-Diet-Induced Colitis In Vivo by Modulating Gut Microbiota and Enhancing SCFAs Synthesis.
新橙皮苷通过调节肠道菌群和增强短链脂肪酸合成，减轻体内高脂饮食引起的结肠炎
Colon-Targeted Mucoadhesive PLGA Microspheres Loaded with Ramulus Mori Alkaloids for Enhanced Water-Soluble Drug Delivery in Ulcerative Colitis Treatment.
载有桑枝生物碱的结肠靶向粘膜粘附性PLGA微球，用于增强溃疡性结肠炎治疗中的水溶性药物递送
Proteus mirabilis exacerbates ulcerative colitis by inhibiting mucin production.
奇异变形杆菌通过抑制粘蛋白的产生而加剧溃疡性结肠炎
- 1
- 2
- 3
- 4
- 5