用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | A431 cells, HEK-293 cells, mouse brain tissue, HeLa cells, HepG2 cells, rat brain tissue, HEK-293T cells, L02 cells, mouse liver tissue |
| Positive IP detected in | mouse brain tissue |
| Positive IHC detected in | mouse brain tissue, mouse heart tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive FC (Intra) detected in | HeLa cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
OPA1 is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. OPA1 localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. OPA1 is associated with the inner membrane and protects cells from apoptosis by regulating inner membrane dynamics. Mutation of OPA1 causes the disease dominant optic atrophy, a degeneration of the retinal ganglion cells. OPA1 undergoes complex posttranscriptional regulation and posttranslational proteolysis. OPA1 is regulated by proteolytic cleavage, which degrades long OPA1 isoforms into short isoforms. The gene OPA1 can be cleaved into some chains with MW 100 kDa and 80-90 kDa.
文献引用 (76)
Dual regulation of mitochondrial fusion by Parkin-PINK1 and OMA1.
Parkin-PINK1 和 OMA1 对线粒体融合的双重调控
The crucial function of IDO1 in pulmonary fibrosis: From the perspective of mitochondrial fusion in lung fibroblasts and targeted molecular inhibition.
IDO1 在肺纤维化中的关键作用：从肺成纤维细胞线粒体融合和靶向分子抑制的角度
Differential pathological dynamics triggered by distinct Parkinson patient-derived α-synuclein extracts in nonhuman primates.
帕金森病患者来源的α-突触核蛋白提取物在非人灵长类动物中引发的差异性病理动力学
Calcium dysregulation disrupts mitochondrial homeostasis by interfering AMPK/Drp1 pathway to aggravate plaque progression and instability
钙稳态失衡会干扰 AMPK/Drp1 通路，从而破坏线粒体稳态，加剧斑块进展和不稳定性。
USP10 protects against pressure overload-induced mitochondrial morphofunctional defects and pathological cardiac hypertrophy through stabilizing cytoplasmic Mfn2.
USP10 通过稳定细胞质 Mfn2 来防止压力超负荷引起的线粒体形态功能缺陷和病理性心脏肥大
Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress
推测的PINK1/Parkin激活因子通过增强细胞对线粒体应激的敏感性来降低线粒体自噬的阈值。
Mitochondrial ultrastructural pathology in diabetic cardiomyopathy: integrated analysis via scanning electron microscopy and 3D visualization imaging.
糖尿病心肌病线粒体超微结构病理学：通过扫描电子显微镜和 3D 可视化成像进行综合分析
Radiocleavable rare-earth nanoactivators targeting over-expressed folate receptors induce mitochondrial dysfunction and remodel immune suppressive microenvironment in pancreatic cancer
靶向过度表达的叶酸受体的放射性可裂解稀土纳米激活剂可诱导线粒体功能障碍并重塑胰腺癌中的免疫抑制微环境
sLithospermic acid etched ZIF-8 nanoparticles delays osteoarthritis progression by inhibiting inflammatory signaling pathways and rescuing mitochondrial damage.
紫草酸蚀刻的 ZIF-8 纳米颗粒通过抑制炎症信号通路和修复线粒体损伤来延缓骨关节炎的进展
Exogenous SPD inhibits trastuzumab-mediated cardiomyocyte pyroptosis through SIRT3-regulated mitochondrial quality control.
外源性 SPD 通过 SIRT3 调节的线粒体质量控制抑制曲妥珠单抗介导的心肌细胞焦亡
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