用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HCT 116 cells, HL-60 cells, HEK-293 cells, Jurkat cells, mouse brain tissue, rat brain tissue |
| Positive IP detected in | rat testis tissue |
| Positive IF-P detected in | rat testis tissue |
| Positive FC (Intra) detected in | HeLa cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
GPX4 (Phospholipid hydroperoxide glutathione peroxidase, mitochondrial) protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility.It has two isforms about 20KDa and 22KDa, respectively. GPX4 is a monomer,but it has a tendency to form higher mass oligomers (PMID:17630701). It presents primarily in testis.
文献引用 (39)
Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes
可注射的 ECM 模拟动态水凝胶通过递送髓核祖细胞衍生的外泌体来消除铁死亡诱导的椎间盘切除术后疝。
Eriodictyol-cisplatin coated nanomedicine synergistically promote osteosarcoma cells ferroptosis and chemosensitivity.
圣草酚-顺铂包覆纳米药物协同促进骨肉瘤细胞铁死亡和化疗敏感性
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation.
SLC25A1 和 ACLY 维持胞质乙酰辅酶A，并通过 FSP1 乙酰化调节铁死亡敏感性
TRIM32 promotes neuronal ferroptosis by enhancing K63-linked ubiquitination and subsequent p62-selective autophagic degradation of GPX4
TRIM32 通过增强 K63 连接的泛素化和随后的 p62 选择性自噬降解 GPX4 来促进神经元铁死亡
Ferroptosis emerges as the predominant form of regulated cell death in goat sperm cryopreservation
铁死亡成为山羊精子冷冻保存中受调节细胞死亡的主要形式
Synergistic Antioxidant and Anti-Ferroptosis Therapy via BPNS-Encapsulated Thermoresponsive Chitosan Hydrogel for Spinal Cord Injury Regeneration.
通过 BPNS 包封的热响应性壳聚糖水凝胶进行协同抗氧化和抗铁死亡疗法，用于脊髓损伤再生
Hydrogen Sulfide Sustained Release Donor Alleviates Spinal Cord Ischemia-Reperfusion-Induced Neuron Death by Inhibiting Ferritinophagy-Mediated Ferroptosis.
硫化氢缓释供体通过抑制铁蛋白自噬介导的铁死亡来减轻脊髓缺血再灌注引起的神经元死亡
Folic Acid Ameliorates Neuronal Ferroptosis in Aging by Up-Regulating SLC7A11-GSH-GPX(4) Antioxidant Pathway and Increasing Cystine Levels.
叶酸通过上调 SLC7A11-GSH-GPX(4) 抗氧化途径和增加胱氨酸水平来改善衰老过程中的神经元铁死亡
Linoleic acid metabolite 13-Hydroxyoctadecadienoic acid as a biphasic ferroptosis modulator in granulosa cells: multi-omics analysis of ovine atretic follicles
亚油酸代谢产物13-羟基十八碳二烯酸作为颗粒细胞中双相铁死亡调节剂：绵羊闭锁卵泡的多组学分析
The pivotal regulatory role of the FEV-SLC7A11 axis in ferroptosis elucidates the anti-aging mechanism of β-sitosterol in a cross-species study
跨物种研究表明，FEV-SLC7A11轴在铁死亡中起着关键的调控作用，从而阐明了β-谷甾醇的抗衰老机制。
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