用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive IP detected in | U-937 cells |
| Positive IHC detected in | human tonsillitis tissue, human appendicitis tissue, human lymphoma tissue, Jurkat cells Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | human appendicitis tissue, human tonsillitis tissue |
| Positive IF/ICC detected in | MCF-7 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
1) What is Bcl-2? Bcl-2 (B-cell lymphoma 2) is an outer mitochondrial membrane protein that via heterodimerization with BAX proteins controls apoptosis. Abnormalities of Bcl-2 activity can lead to cancer, autoimmune diseases, and schizophrenia. 2) FAQs for Bcl-2 A) How to measure Bcl-2 and Bax apoptotic markers by western blotting Generally, Bcl-2 protein is considered to have anti-apoptotic activity, while Bax has apoptotic activity. Comparing the ratio between Bcl-2 and Bax protein levels in different samples or cells subjected to treatments can reflect the apoptotic state of the cells. Expression of Bax can vary between cell lines and it is important to compare it to Bcl-2 levels. B) What band size should I expect in western blotting for Bcl-2? The molecular weight of Bcl-2 is 26 kDa.
文献引用 (95)
Integrative proteogenomic characterization reveals therapeutic targets in poorly differentiated and anaplastic thyroid cancers.
整合蛋白质基因组学表征揭示了分化不良和未分化甲状腺癌的治疗靶点
Madecassoside mitigates acute myocardial infarction injury by activating the PKCB/SPARC signaling pathway.
积雪草苷通过激活 PKCB/SPARC 信号通路减轻急性心肌梗死损伤
Enhancing pancreatic cancer treatment: the role of H101 oncolytic virus in irreversible electroporation.
增强胰腺癌治疗：H101溶瘤病毒在不可逆电穿孔中的作用
Icariin interacts with IGFBP3 to alleviate diabetic cataract through PI3K/AKT signaling pathway.
淫羊藿苷通过PI3K/AKT信号通路与IGFBP3相互作用，从而缓解糖尿病性白内障
Mitochondrial-dependent apoptosis and STAT3 activation induced by oxidative stress in pemphigus vulgaris.
寻常型天疱疮中氧化应激诱导的线粒体依赖性细胞凋亡和 STAT3 激活
Reg3β promotes chondrocyte proliferation and ECM metabolism during acetabular roof remodeling in a rat model of DDH‑induced residual dysplasia
Reg3β在DDH诱导的残余发育不良大鼠模型中促进髋臼顶重塑过程中的软骨细胞增殖和ECM代谢
Exploring the Molecular Mechanism of 1,25(OH)(2)D(3) Reversal of Sorafenib Resistance in Hepatocellular Carcinoma Based on Network Pharmacology and Experimental Validation.
基于网络药理学和实验验证，探索 1,25(OH)2D3 逆转肝细胞癌索拉非尼耐药性的分子机制
VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation
VHL 通过 PHD1 依赖的 Beclin1 羟基化抑制自噬和肿瘤生长
Neuroprotective effects of apigenin on retinal ganglion cells in ischemia/reperfusion: modulating mitochondrial dynamics in in vivo and in vitro models
芹菜素对缺血/再灌注视网膜神经节细胞的神经保护作用：调节体内和体外模型中的线粒体动力学
METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1
METTL3通过YTHDC1介导lncRNA CRNDE的m6A修饰促进ATG10表达并改善脑缺血/再灌注损伤
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