AKT Monoclonal antibody (60203-2-Ig)
AKT 1; AKT1; EC:2.7.11.1; PKB
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | A549 cells, HEK-293 cells, mouse brain tissue, ROS1728 cells, LNCaP cells, Hela cells, Jurkat cells, HSC-T6 cells, PC-12 cells, NIH/3T3 cells |
| Positive IP detected in | mouse brain tissue |
| Positive IHC detected in | mouse lung tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | MCF-7 cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. This antibody detects all the members of AKT with/without phospho- modification.
文献引用 (241)
Chimeric antigen receptor with novel intracellular modules improves antitumor performance of T cells
具有新型胞内模块的嵌合抗原受体可提高T细胞的抗肿瘤活性
A Dual Approach with Organoid and CRISPR Screening Reveals ERCC6 as a Determinant of Cisplatin Resistance in Osteosarcoma.
采用类器官和 CRISPR 筛选的双重方法揭示 ERCC6 是骨肉瘤顺铂耐药性的决定因素
Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia.
Arf1 缺失神经元中有害脂质的积累通过释放 mtDNA 和激活小胶质细胞中的炎症通路促进神经退行性变
AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple-Negative Breast Cancer.
AKT1 磷酸化 FDX1 以促进三阴性乳腺癌细胞的铜凋亡抵抗
Nanodelivery of Y-27632 by RGD-modified liposome enhances radioimmunotherapy of hepatocellular carcinoma via tumor microenvironment matrix stiffness reprogramming.
通过RGD修饰的脂质体纳米递送Y-27632，通过肿瘤微环境基质硬度重编程增强肝细胞癌的放射免疫疗法
Integrated stress response activation induced by usnic acid alleviates BCL-2 inhibitor ABT-199 resistance in acute myeloid leukemia.
松萝酸诱导的整合应激反应激活可缓解急性髓系白血病中 BCL-2 抑制剂 ABT-199 的耐药性
The direct and indirect inhibition of proinflammatory adipose tissue macrophages by acarbose in diet-induced obesity
阿卡波糖对饮食诱导肥胖中促炎性脂肪组织巨噬细胞的直接和间接抑制作用
Pharmacological inhibition of Septins with Forchlorfenuron attenuates thrombus formation in experimental thrombotic mice models with modulating multiple signaling pathways in platelets
在实验性血栓小鼠模型中，使用氯苯脲进行Septin蛋白的药理学抑制可减轻血小板中多种信号通路介导的血栓形成。
Troxerutin suppresses the stemness of osteosarcoma via the CD155/SRC/β-catenin signaling axis.
曲克芦丁通过 CD155/SRC/β-catenin 信号轴抑制骨肉瘤的干性
Sustained release of miR-21 carried by mesenchymal stem cell-derived exosomes from GelMA microspheres inhibits ovarian granulosa cell apoptosis in premature ovarian insufficiency.
GelMA微球中间充质干细胞来源的外泌体持续释放miR-21，可抑制卵巢早衰中卵巢颗粒细胞的凋亡
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