Vimentin Monoclonal antibody (60330-1-Ig)
VIM
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | HeLa cells, NIH/3T3 cells, ROS1728 cells, Jurkat cells, A549 cells, U2OS cells, U-251 cells |
| Positive IHC detected in | human appendicitis tissue, human breast cancer tissue, human colon tissue, human endometrial cancer tissue, human liver cancer tissue, human ovary tumor tissue, human pancreas tissue, human renal cell carcinoma tissue, human tonsillitis tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | HUVEC cells, HepG2 cells, Retinal organoids |
| Positive FC (Intra) detected in | HeLa cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Vimentin, also named as VIM, belongs to the intermediate filament family. Vimentin is class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is important for stabilizing the architecture of the cytoplasm. Monocyte-derived macrophages secrete vimentin into the extracellular space in vitro. Secretion of vimentin was enhanced by the proinflammatory cytokine tumor necrosis factor-alpha (TNFA; 191160) and inhibited by the antiinflammatory cytokine IL10 (124092), suggesting that vimentin is involved in the immune response. Vimentin has specialized functions that contribute to specific dynamic cellular processes. As a phosphoprotein, 55-60 kDa of vimentin proteins can be observed due to the different phosphorylation level.
文献引用 (118)
Neoadjuvant Chemotherapy With Cisplatin Up-Regulates GSDMD to Enhance Oral Squamous Cell Carcinoma Metastasis Through MMP14-Mediated EMT Activation.
顺铂新辅助化疗通过 MMP14 介导的 EMT 激活上调 GSDMD，从而增强口腔鳞状细胞癌的转移
USP10 protects against pressure overload-induced mitochondrial morphofunctional defects and pathological cardiac hypertrophy through stabilizing cytoplasmic Mfn2.
USP10 通过稳定细胞质 Mfn2 来防止压力超负荷引起的线粒体形态功能缺陷和病理性心脏肥大
Thermosensitive hydrogel composite with si-Cx43 nanoparticles and anti-VEGF agent for synergistic treatment of diabetic retinopathy.
含有si-Cx43纳米颗粒和抗VEGF剂的热敏水凝胶复合材料，用于协同治疗糖尿病视网膜病变
Elastin-like polypeptide and triclosan-modified PCL membrane provides aseptic protection in tissue regeneration.
弹性蛋白样多肽和三氯生修饰的PCL膜在组织再生中提供无菌保护
Inhibition of Mettl3 alleviates low-dose cisplatin-induced renal fibrosis and enhances the chemotherapeutic efficacy in mouse models of cancer.
抑制 Mettl3 可减轻低剂量顺铂引起的肾纤维化，并增强癌症小鼠模型的化疗疗效
ZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer.
ZC3H13 介导 SNTB1 的 N6-甲基腺苷修饰，从而促进胃癌的上皮-间质转化
Senescent fibroblasts secrete CTHRC1 to promote cancer stemness in hepatocellular carcinoma.
衰老成纤维细胞分泌 CTHRC1 以促进肝细胞癌的干性
CILP1 interacting with YBX1 promotes hypertrophic scar formation by suppressing PPARs transcription
CILP1与YBX1相互作用，通过抑制PPARs转录促进肥厚性瘢痕形成。
Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy.
利用 2D 和 3D 人类子宫内膜细胞培养模型研究 SARS-CoV-2 在妊娠早期的感染情况
The CD163â+âtissue-infiltrating macrophages regulate ferroptosis in thyroid-associated ophthalmopathy orbital fibroblasts via the TGF-β/Smad2/3 signaling pathway.
CD163+组织浸润巨噬细胞通过TGF-β/Smad2/3信号通路调节甲状腺相关眼病眼眶成纤维细胞的铁死亡
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