Lamin B1 Monoclonal antibody (66095-1-Ig)
LMNB1; laminB1; Lamin-B1; LMN2
用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | NCI-H1299 cells, multi-cells/tissue, HeLa cells, HepG2 cells, HEK-293 cells, Jurkat cells, K-562 cells, PC-12 cells, NIH/3T3 cells, 4T1cells |
| Positive IP detected in | HeLa cells |
| Positive IHC detected in | human pancreas cancer tissue, human breast cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | mouse eye tissue |
| Positive IF/ICC detected in | HepG2 cells, HeLa cells |
| Positive FC (Intra) detected in | HeLa cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. This protein is not suitable for samples where the nuclear envelope has been removed.
文献引用 (163)
Lig3-dependent rescue of mouse viability and DNA double-strand break repair by catalytically inactive Lig4
通过催化失活的lig3依赖性挽救小鼠生存能力和修复DNA双链断裂lig4
Nuclear ANLN regulates transcription initiation related Pol II clustering and target gene expression
核 ANLN 调节转录起始相关的 Pol II 聚集和靶基因表达
HDAC2-Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple-Negative Breast Cancer.
HDAC2介导的METTL3去乙酰化促进三阴性乳腺癌的DNA损伤修复和化疗耐药性
RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development.
RACK7 与 PRC2 复合物相互作用以调节星形胶质细胞发育
SUMOylation of SARS-CoV-2 spike protein is a key target for broad-spectrum antiviral therapy.
SARS-CoV-2 刺突蛋白的 SUMO 化是广谱抗病毒疗法的关键靶点
PPDPF preserves integrity of proximal tubule by modulating NMNAT activity in chronic kidney diseases.
PPDPF 通过调节 NMNAT 活性来维持慢性肾脏疾病中近端肾小管的完整性
Depletion of Fat Mass and Obesity-Associated Protein (FTO) Drives Heterochromatin Loss via Lysine Acetyltransferase 8 (KAT8)-Mediated Remodeling and Spacing Factor 1 (RSF1) Acetylation in Skin Aging.
脂肪量和肥胖相关蛋白 (FTO) 的消耗通过赖氨酸乙酰转移酶 8 (KAT8) 介导的重塑和间隔因子 1 (RSF1) 乙酰化驱动皮肤老化过程中的异染色质丢失
A thermosensitive hydrogel with synergistic stromal targeting and antitumor immunity modulation for pancreatic cancer immunotherapy.
一种具有协同基质靶向和抗肿瘤免疫调节作用的热敏水凝胶，用于胰腺癌免疫治疗
Decursin induces FLT3-ITD acute myeloid leukemia cell apoptosis by increasing the expression of the ubiquitin-conjugase UBE2L6.
Decursin 通过增加泛素结合酶 UBE2L6 的表达来诱导 FLT3-ITD 急性髓系白血病细胞凋亡
ApoM maintains cellular homeostasis between mitophagy and apoptosis by affecting the stability of Nnt mRNA through the Zic3-ApoM-Elavl2-Nnt axis during neural tube closure
ApoM 在神经管闭合过程中通过 Zic3-ApoM-Elavl2-Nnt 轴影响 Nnt mRNA 的稳定性，从而维持线粒体自噬和细胞凋亡之间的细胞稳态
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