用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | U-87 MG cells, Recombinant protein, Jurkat cells, HUVEC cells |
| Positive IF/ICC detected in | LPS and Brefeldin A treated HUVEC cells |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. IL-6 plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. IL-6 is also considered a myokine, a cytokine produced from muscle, and is elevated in response to muscle contraction. IL-6 has been shown to interact with interleukin-6 receptor and glycoprotein 130. Additionally, IL-6 is involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.
文献引用 (66)
Dysregulation of gut microbiota stimulates NETs-driven HCC intrahepatic metastasis: therapeutic implications of healthy faecal microbiota transplantation.
肠道菌群失调刺激NETs驱动的HCC肝内转移：健康粪便菌群移植的治疗意义
Activation of pregnane X receptor protects against cholestatic liver injury by inhibiting hepatocyte pyroptosis.
孕烷X受体的激活通过抑制肝细胞焦亡来保护肝脏免受胆汁淤积性损伤
Two-in-one: multifunctional poloxamer hydrogel accelerates endometrial regeneration and fertility restoration through synergistic regulation of KGF-2 and NO.
二合一：多功能泊洛沙姆水凝胶通过协同调节 KGF-2 和 NO 来加速子宫内膜再生和生育力恢复
Ganoderic Acid A Alleviates Severe Acute Pancreatitis by Modulating Gut Homeostasis and Inhibiting TLR4-NLRP3 Signaling.
灵芝酸A通过调节肠道稳态和抑制TLR4-NLRP3信号传导来缓解重症急性胰腺炎
Hyperoxia-activated Nrf2 regulates ferroptosis in intestinal epithelial cells and intervenes in inflammatory reaction through COX-2/PGE2/EP2 pathway
高氧激活Nrf2通过COX-2/PGE2/EP2通路调控肠上皮细胞铁死亡并干预炎症反应
Yuye Jinhua Qingre Tablets Attenuate Acute Pharyngitis by inhibiting the Complement Cascade and C5a/C5aR1 Axis.
玉叶金花清热片通过抑制补体级联反应和C5a/C5aR1轴来缓解急性咽炎
Using Cancer-Associated Fibroblasts as a Shear-Wave Elastography Imaging Biomarker to Predict Anti-PD-1 Efficacy of Triple-Negative Breast Cancer.
利用癌症相关成纤维细胞作为剪切波弹性成像生物标志物预测抗PD-1治疗三阴性乳腺癌的疗效
Natural Killer Cell Activation Signature Identifies Cyclin B1/CDK1 as a Druggable Target to Overcome Natural Killer Cell Dysfunction and Tumor Invasiveness in Melanoma.
自然杀伤细胞激活特征表明细胞周期蛋白 B1/CDK1 可作为药物靶点，以克服黑色素瘤中自然杀伤细胞功能障碍和肿瘤侵袭性
Yersiniabactin produced by Escherichia coli promotes intestinal inflammation through lipid peroxidation and ferroptosis
大肠杆菌产生的耶尔森菌素通过脂质过氧化和铁死亡促进肠道炎症
Analysis of histone modifications in key cellular subpopulations in the context of azoospermia using spermatogenic single-cell RNA-seq data.
利用精子发生单细胞 RNA-seq 数据分析无精子症关键细胞亚群中的组蛋白修饰
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