用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | rabbit brain tissue, pig brain tissue, human heart tissue, MKN-45 cells, HEK-293 cells, PC-3 cells, mouse brain tissue, rat brain tissue, C2C12 cells, C6 cells, Saos-2 cells, SGC-7901 cells, ROS1728 cells, NIH/3T3 cells |
| Positive IHC detected in | mouse heart tissue, mouse brain tissue, human malignant melanoma tissue, human ovary tumor tissue, rat heart tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF-P detected in | mouse heart tissue |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. N-cadherin (neural cadherin), also known as CDH2 (cadherin 2), is a 130-kDa transmembrane protein and a classical member of the cadherin superfamily which also include E-, P-, R-, and B-cadherins. Expression of N-cadherin has been reported on various cell types including neurons, endothelial cells and cardiac myocytes (PMID: 11282032; 9508779; 8125202). N-cadherin has functions in early brain morphogenesis, synaptogenesis and synaptic plasticity (PMID: 23321619). The N-cadherin ectodomain can be cleaved, leading to the generation of a 90 kD N-terminal fragment (PMID: 16998833; 17028923).
文献引用 (80)
Biological Reinforced Concrete for Cartilage Repair With 3D Printing.
利用3D打印技术制备生物增强混凝土用于软骨修复
Excessive MYC Orchestrates Macrophages induced Chromatin Remodeling to Sustain Micropapillary-Patterned Malignancy in Lung Adenocarcinoma.
MYC 过量调控巨噬细胞诱导的染色质重塑，以维持肺腺癌中的微乳头状恶性肿瘤
ZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer.
ZC3H13 介导 SNTB1 的 N6-甲基腺苷修饰，从而促进胃癌的上皮-间质转化
NID2 Affects Prognosis of Glioma via Activating the Akt Signaling Pathway.
NID2 通过激活 Akt 信号通路影响胶质瘤的预后
tRF-34-P4R8YP9LON4VHM Promotes Hepatocellular Carcinoma Progression and Tumour Cell-Induced Angiogenesis via the MEK/ERK Pathway.
tRF-34-P4R8YP9LON4VHM 通过 MEK/ERK 通路促进肝细胞癌进展和肿瘤细胞诱导的血管生成
STEAP3 promotes triple-negative breast cancer growth through the FGFR1-mediated activation of PI3K/AKT/mTOR signaling.
STEAP3 通过 FGFR1 介导的 PI3K/AKT/mTOR 信号通路激活促进三阴性乳腺癌的生长
XBP1 promotes endometrial fibrosis through cGAS-STING signaling pathway in intrauterine adhesion.
XBP1 通过 cGAS-STING 信号通路促进子宫内膜纤维化，从而导致宫腔粘连
The molecular subtype based on cell cycle-related gene signature predicts the prognosis and chemotherapy and immunotherapy response in gastric cancer.
基于细胞周期相关基因特征的分子亚型可以预测胃癌的预后以及化疗和免疫治疗反应
Effect of miR-6767-5p on breast cancer cell phenotype and its regulatory mechanism.
miR-6767-5p对乳腺癌细胞表型的影响及其调控机制
UHRF1 promotes epithelial-mesenchymal transition mediating renal fibrosis by activating the TGF-β/SMAD signaling pathway
UHRF1通过激活TGF-β/SMAD信号通路促进上皮-间质转化，介导肾脏纤维化
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