用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | RAW 264.7 cells, J774A.1 cells, NIH/3T3 cells, pig liver tissue, rat liver tissue |
| Positive IHC detected in | human tonsillitis tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
推荐稀释说明
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. Sample-dependent, Check data in validation data gallery.
详细信息
背景信息
TLR4, also named CD284, belongs to the Toll-like receptor family. TLR4 interacts with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). TLR4 acts via MYD88, TIRAP and TRAF6, leading to NF-kB activation, cytokine secretion, and the inflammatory response. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
文献引用 (62)
CXCL10 secreted by SPRY1-deficient epidermal keratinocytes fuels joint inflammation in psoriatic arthritis via CD14 signaling.
SPRY1 缺陷的表皮角质形成细胞分泌的 CXCL10 通过 CD14 信号传导加剧银屑病关节炎的关节炎症
Mn(3)O(4) nanozyme-based anti-inflammatory therapy modulates microglial phenotype by downregulating TLR4/NOX2 expression and further alleviates Alzheimer's disease pathology.
基于 Mn(3)O(4) 纳米酶的抗炎疗法通过下调 TLR4/NOX2 表达来调节小胶质细胞表型，并进一步减轻阿尔茨海默病病理
Probiotics alleviate painful diabetic neuropathy by modulating the microbiota-gut-nerve axis in rats
益生菌通过调节大鼠的微生物-肠道-神经轴来缓解糖尿病疼痛性神经病变
Harnessing dual-channel probiotics to synergistically correct intestinal and vaginal dysbiosis after antibiotic disruption.
利用双通道益生菌协同纠正抗生素破坏后的肠道和阴道菌群失调
Ginseng-derived nanoparticles accelerate diabetic wound healing by modulating macrophage polarization and restoring endothelial cell function
人参纳米颗粒通过调节巨噬细胞极化和恢复内皮细胞功能来加速糖尿病伤口愈合。
SVHRSP protects against rotenone-induced neurodegeneration in mice by inhibiting TLR4/NF-κB-mediated neuroinflammation via gut microbiota
SVHRSP 通过肠道微生物群抑制 TLR4/NF-κB 介导的神经炎症，防止小鼠因鱼藤酮诱发的神经退行性病变
Exploring the possible mechanism of low-dose naloxone exposure improving the immune microenvironment of gastric cancer tumors
探索低剂量纳洛酮暴露改善胃癌肿瘤免疫微环境的可能机制
Curdione combined with borneol treats bacterial mixed HPV infection by regulating the crosstalk among immune cells
莪术二酮联合冰片通过调节免疫细胞间的串扰治疗细菌混合型HPV感染
Deep-Sea-Derived Isobisvertinol Targets TLR4 to Exhibit Neuroprotective Activity via Anti-Inflammatory and Ferroptosis-Inhibitory Effects.
深海来源的异双维替醇靶向 TLR4，通过抗炎和抑制铁死亡作用发挥神经保护活性
Combating Traumatic Brain Injury: A Dual-Mechanism Hydrogel Delivering Salvianolic Acid A and Hydroxysafflor Yellow A to Block TLR4/NF-κB and Boost Angiogenesis.
对抗创伤性脑损伤：一种双重机制水凝胶，输送丹酚酸 A 和羟基红花黄 A，以阻断 TLR4/NF-αB 并促进血管生成
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