Anti-FTO antibody [EPR6895] (Ab124892)

KIAA1752, FTO, Alpha-ketoglutarate-dependent dioxygenase FTO, Fat mass and obesity-associated protein, U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO, U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO, mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO, mRNA N(6)-methyladenosine demethylase FTO, tRNA N1-methyl adenine demethylase FTO, m6A(m)-demethylase FTO

反应种属:Human
抗原名称:FTO
应用:WB, IHC

用户验证的应用

推荐稀释比例

  • IHC-P1/100 - 1/250 Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.
  • WB1/1000 - 1/10000

详细信息

免疫原The exact immunogen used to generate this antibody is proprietary information.
宿主/亚型Rabbit / IgG
抗体类型Monoclonal
全称Anti-FTO antibody [EPR6895]
产品形式Liquid
储存缓冲液pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
储存条件运输条件: Conditional Ambient 推荐的短期储存条件: +4°C 推荐的长期储存条件: -20°C 储存信息: Stable for 12 months at -20°C
纯化方式Affinity purification Protein A

背景信息

Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.

文献引用 (63)

Integrative single-cell, spatial, and bulk transcriptomics reveal an FMR1-FTO axis linked to the immune-excluded phenotype in gastric cancer.

整合的单细胞、空间和整体转录组学揭示了与胃癌免疫排斥表型相关的 FMR1-FTO 轴。

Mao Chenxi, Zhang Miao, Zhou Kangjie, Hong Yidong, Han Yiqian, Zhao Luming, Liang Mingtong, Zhang Jingzhou, Hu Nan, Wu Fenglei

Insulin signaling pathway related m(6)A methylated biomarker for type 2 diabetes and the potential modulation mechanism.

胰岛素信号通路相关m(6)A甲基化生物标志物与2型糖尿病及其潜在调节机制。

Dong Jing, Zhang Yu, Li Yan-Ling, Wu Li-Juan, Wang Shuo, Chen Ning, Yan Yu-Xiang

Ginsenoside Rb1 mitigates atherosclerosis in part through modulating FTO-mediated m6A RNA modification in NETs-induced endothelial activation

人参皂苷Rb1通过调节NETs诱导的内皮细胞活化过程中FTO介导的m6A RNA修饰,部分缓解动脉粥样硬化。

Zhenni Yang ,Minqi Xiong ,Xinmiao Tang ,Peiwei Wang ,Jingang Cui ,Yu Chen ,Teng Zhang

The pseudorabies virus UL13 protein kinase triggers phosphorylation of the RNA demethylase FTO, which is associated with FTO-dependent suppression of interferon-stimulated gene expression

伪狂犬病毒 UL13 蛋白激酶触发 RNA 去甲基化酶 FTO 的磷酸化,这与 FTO 依赖性抑制干扰素刺激的基因表达有关

Ruth Verhamme #, Robert J J Jansens #, Jianheng Liu, Fien Van Raemdonck, Cliff Van Waesberghe, Luke Nicholson, Samie R Jaffrey #, Herman W Favoreel #

Curcumin-induced exosomal FTO from bone marrow stem cells alleviates sepsis-associated acute kidney injury by modulating the m6A methylation of OXSR1

姜黄素诱导的骨髓干细胞外泌体FTO通过调节OXSR1的m6A甲基化来减轻脓毒症相关的急性肾损伤

Ting Yang,Hui Yu,Zheng Xie

Reduced Expression of m6A Demethylases FTO and ALKBH5 in Monocytes from the Site of Inflammation in Patients with Juvenile Idiopathic Arthritis

幼年特发性关节炎患者炎症部位单核细胞中m6A去甲基酶FTO和ALKBH5表达降低

Hisham I Abu-Tawil ,Lucas W Picavet ,Ellen C N van Vroonhoven ,Alejandra Bodelón ,Rianne C Scholman ,Nienke Ter Haar ,Arjan Boltjes ,Sebastiaan J Vastert ,Jorg van Loosdregt

Discovery of a potent PROTAC degrader for RNA demethylase FTO as antileukemic therapy

发现 RNA 去甲基化酶 FTO 的强效 PROTAC 降解剂,可用于抗白血病治疗

Lu Liu, Yuanlai Qiu, Yuying Suo, Siyao Tong, Yiqing Wang, Xi Zhang, Liang Chen, Yue Huang, Huchen Zhou, Hu Zhou, Ze Dong, Cai-Guang Yang

LOX-1 acts as an N6-methyladenosine-regulated receptor for Helicobacter pylori by binding to the bacterial catalase

LOX-1 通过与细菌过氧化氢酶结合,充当幽门螺杆菌的 N6-甲基腺苷调节受体

Judeng Zeng #, Chuan Xie #, Ziheng Huang, Chi H Cho, Hung Chan, Qing Li, Hassan Ashktorab, Duane T Smoot, Sunny H Wong, Jun Yu, Wei Gong, Cong Liang, Hongzhi Xu, Huarong Chen, Xiaodong Liu, Justin C Y Wu, Margaret Ip, Tony Gin, Lin Zhang, Matthew T V Chan, Wei Hu, William K K Wu

FSH induces EMT in ovarian cancer via ALKBH5-regulated Snail m6A demethylation

FSH通过ALKBH5调控的Snail m6A去甲基化诱导卵巢癌EMT

Xingyan Xu ,Xuefen Zhuang ,Haowei Yu ,Ping Li ,Xiaosa Li ,Huiping Lin ,Jian-Peng Teoh ,Yiwen Chen ,Yuanlan Yang ,Yang Cheng ,Weiyu Chen ,Xiaodong Fu

ZFHX3 acts as a tumor suppressor in prostate cancer by targeting FTO-mediated m6A demethylation

ZFHX3 通过靶向 FTO 介导的 m6A 去甲基化,在前列腺癌中发挥肿瘤抑制作用

Qingxia Hu, Junling Yin, Sijie Zhao, Yibo Wang, Ruxue Shi, Keqiang Yan, Shuhong Huang
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