Anti-FTO antibody [EPR6894] (Ab126605)
KIAA1752, FTO, Alpha-ketoglutarate-dependent dioxygenase FTO, Fat mass and obesity-associated protein, U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO, U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO, mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO, mRNA N(6)-methyladenosine demethylase FTO, tRNA N1-methyl adenine demethylase FTO, m6A(m)-demethylase FTO
用户验证的应用
推荐稀释比例
- IHC-P1/500 For unpurified, use 1/50 - 1/100.
- WB1/10000 - 1/20000 For unpurified, use 1/1000 - 1/10000.
- ICC/IF1/250 For unpurified, use 1/50 - 1/100.
详细信息
背景信息
What is this antibody validated in? Anti-FTO antibody [EPR6894] (ab126605) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples. What is the molecular weight of FTO? Anti-FTO [EPR6894] (ab126605) specifically detects a band for FTO (UniProt: Q9C0B1) at a molecular weight of 58kDa. Trusted by the scientific community Anti-FTO [EPR6894] (ab126605) was first used in a scientific publication in 2012 and has been cited over 30 times in peer-reviewed journals. Specificity confirmed The specificity of Anti-FTO antibody [EPR6894] (ab126605) has been confirmed by Western blot testing in FTO Knockout HAP1 cells. Other related products We have a range of other formats of antibody clone [EPR6894] also available for your convenience: ab126605, Alexa Fluor® 488 - ab207665, Carrier free - ab240021 Species reactivity Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 20µl. Discover our selection of trial-size antibodies.
文献引用 (88)
Elevated FTO alleviates sepsisâinduced acute kidney injury by regulating macrophage inflammatory phenotypes.
FTO 升高可通过调节巨噬细胞炎症表型来减轻脓毒症引起的急性肾损伤。
N6-methyladenosine within transmissible gastroenteritis virus genomic RNA inhibits its replication via efficient recognition by RNA sensor RIG-I.
传染性胃肠炎病毒基因组 RNA 中的 N6-甲基腺苷通过 RNA 传感器 RIG-I 的有效识别抑制其复制。
MicroRNAâ199aâ3p suppresses nonâsmall cell lung cancer progression by targeting FTO to enhance m6Aâmediated downregulation of MZF1 and its transcriptional activation of CLDND1.
MicroRNA'199a'3p 通过靶向 FTO 来抑制非小细胞肺癌的进展，从而增强 m6A' 介导的 MZF1 下调及其对 CLDND1 的转录激活。
METTL14 knockdown mitigates HG-induced HK-2 cell apoptosis, inflammation, and ferroptosis by promoting SLC40A1.
METTL14 敲低通过促进 SLC40A1 来减轻 HG 诱导的 HK-2 细胞凋亡、炎症和铁死亡。
FTO suppresses DNA repair by inhibiting PARP1.
FTO通过抑制PARP1来抑制DNA修复
BRD4 regulates m(6)A of ESPL1 mRNA via interaction with ALKBH5 to modulate breast cancer progression.
BRD4 通过与 ALKBH5 相互作用来调节 ESPL1 mRNA 的 m(6)A，从而调节乳腺癌的进展
FTO facilitates colorectal cancer chemoresistance via regulation of NUPR1-dependent iron homeostasis.
FTO 通过调节 NUPR1 依赖的铁稳态促进结直肠癌的化疗耐药性
Depletion of Fat Mass and Obesity-Associated Protein (FTO) Drives Heterochromatin Loss via Lysine Acetyltransferase 8 (KAT8)-Mediated Remodeling and Spacing Factor 1 (RSF1) Acetylation in Skin Aging.
脂肪量和肥胖相关蛋白 (FTO) 的消耗通过赖氨酸乙酰转移酶 8 (KAT8) 介导的重塑和间隔因子 1 (RSF1) 乙酰化驱动皮肤老化过程中的异染色质丢失
TNF-α-driven m6A modification disrupts the immunoregulatory function of MSCs by regulating HDAC5-dependent super-enhancers.
TNF-α 驱动的 m6A 修饰通过调节 HDAC5 依赖性超级增强子破坏 MSC 的免疫调节功能。
RNA N(6)-methyladenosine demethylase FTO promotes diabetic wound healing through TRIB3-mediated autophagy in an m(6)A-YTHDF2-dependent manner.
RNA N(6)-甲基腺苷去甲基酶 FTO 通过 TRIB3 介导的自噬以 m(6)A-YTHDF2 依赖的方式促进糖尿病伤口愈合
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