Anti-Fibronectin antibody [EPR23110-46] (Ab268020)

FN, FN1, Fibronectin, Cold-insoluble globulin, CIG

反应种属:Human, Mouse, Rat
抗原名称:FN1
应用:WB, IHC, IF/ICC

用户验证的应用

推荐稀释比例

  • IHC-P1/2000 Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
  • WB1/1000 This product is not suitable for testing mouse and rat tissue samples in western blot.
  • ICC/IF1/50
  • IHC-Fr1/500 Heat mediated antigen retrieval using sodium citrate buffer (10mM citrate pH 6.0 + 0.05% Tween-20).

详细信息

免疫原The exact immunogen used to generate this antibody is proprietary information.
宿主/亚型Rabbit / IgG
抗体类型Monoclonal
全称Anti-Fibronectin antibody [EPR23110-46]
产品形式Liquid
储存缓冲液pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
储存条件运输条件: Conditional Ambient 推荐的短期储存时间: 1-2 weeks 推荐的短期储存条件: +4°C 推荐的长期储存条件: -20°C 储存信息: Avoid freeze / thaw cycle
纯化方式Affinity purification Protein A

背景信息

Anti-Fibronectin antibody [EPR23110-46] (ab268020) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ICC/IF, IHC-Fr, IHC-P, WB in human, mouse, rat samples. Anti-Fibronectin antibody [EPR23110-46] (ab268020) has been cited over 46 times in peer reviewed journals and is trusted by the scientific community. Abcams high quality manufacturing and validation processes ensure Anti-Fibronectin antibody [EPR23110-46] (ab268020) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-Fibronectin antibody [EPR23110-46] (ab268020) has been confirmed by testing in knockout samples. Anti-Fibronectin antibody [EPR23110-46] (ab268020) specifically detects Fibronectin (UniProt ID: P02751; Molecular weight: 269kDa) and is sold in 100 uL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR23110-46 - ab26822. Antibody clone EPR23110-46 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 594, Alexa Fluor® 568, Alexa Fluor® 555, Alexa Fluor® 647, Alexa Fluor® 488, Alexa Fluor® 75 ( ab3964, ab3132, ab313223, ab31335, ab314679, ab321527 ). Fibronectin is a crucial extracellular matrix protein that significantly influences tumor development and progression by enhancing tumor growth, metastasis, and angiogenesis. It interacts with integrin receptors to help tumor cells adapt and survive in harsh microenvironments. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.

文献引用 (140)

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A facile polysaccharide hydrogel activates PPARγ via the Gut-Kidney axis to ameliorate chronic kidney disease.

一种简便的多糖水凝胶通过肠-肾轴激活PPARγ,从而改善慢性肾脏疾病。

Liang Zhuowen, Chen Ali, Lin Huimin, Dong Chen, Huang Qian, Li Longying, Chen Jiayun, Zhang Wei, Huang Xi, Wang Jigang, Chen Kun, Xiao Wei

Senolytics, dasatanib plus quercetin, reduce kidney inflammation, senescent cell abundance, and injury while restoring geroprotective factors in murine diabetic kidney disease.

衰老细胞清除剂达沙替尼加槲皮素可减少小鼠糖尿病肾病中的肾脏炎症、衰老细胞数量和损伤,同时恢复抗衰老因子。

Bian Xiaohui, Snow Zachary K, Zinn Caroline J, Bratulin Anastasia L, Elhusseiny Khaled M, Tchkonia Tamar, Kirkland James L, Zhu Yi, Khosla Sundeep, Kim Seo Rin, Lerman Lilach O, Hickson LaTonya J

Decellularized extracellular matrix restores Fibronectin/Integrin β1 balance through extracellular vesicles to rejuvenate chondrocytes and alleviate osteoarthritis progression.

脱细胞细胞外基质通过细胞外囊泡恢复纤连蛋白/整合素β1平衡,从而使软骨细胞恢复活力并缓解骨关节炎的进展。

Fan Aoyuan, Pang Zhiying, Liu Zheng, Yin Feng, Wang Yiming

LXW7 Peptide Modification of Acellular Liver Scaffolds Improves Endothelialization and Hemocompatibility in Bioengineered Liver.

LXW7肽修饰无细胞肝脏支架可改善生物工程肝脏的内皮化和血液相容性。

Yadav Usha, Yadav Chandra J, Afrin Sadia, Lee Jun-Yeong, Kamel Jihad, Park Kyung-Mee

BMPR2 affects valve development via ECM-receptor interaction in zebrafish.

BMPR2 通过 ECM-受体相互作用影响斑马鱼的瓣膜发育。

Shi Yan, Huang Yanli, Xia Yu, Li Yongqing, Wang Yuequn, Yuan Wuzhou, Li Fang, Jiang Zhigang, Chen Yu, Zhu Ping, Zhuang Jian, Wu Xiushan, Fan Xiongwei

A rat model of Immunologic and hypertensive kidney injury.

免疫性和高血压性肾损伤的大鼠模型。

Hwang Seo-Kyoung, Morin Jeffrey, Houle Christopher, Ravindra Kodihalli C, Newman Leah, Qian Jessie, Vargas Sarah, Olson Jennifer, Lanz Thomas A, Coskran Timothy, Liu Chang-Ning

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G-CSF 促进 H3K27ac 修饰的 KLF5 激活 CXCR4 表达,从而驱动结肠癌的生长和转移。

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