Anti-CD63 antibody [EPR5702] - Late Endosome Marker (Ab134045)

CD63, MLA1, TSPAN30, CD63 antigen, Granulophysin, Lysosomal-associated membrane protein 3, Lysosome integral membrane protein 1, Melanoma-associated antigen ME491, OMA81H, Ocular melanoma-associated antigen, Tetraspanin-30, LAMP-3, Limp1, Tspan-30

反应种属:Human
抗原名称:CD63
应用:WB, IHC

用户验证的应用

推荐稀释比例

  • IHC-P1/2000 For unpurified use at 1/250 - 1/500.
  • WB1/1000 - 1/10000

详细信息

免疫原The exact immunogen used to generate this antibody is proprietary information.
宿主/亚型Rabbit / IgG
抗体类型Monoclonal
全称Anti-CD63 antibody [EPR5702] - Late Endosome Marker
产品形式Liquid
储存缓冲液pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
储存条件运输条件: Conditional Ambient 推荐的短期储存时间: 1-2 weeks 推荐的短期储存条件: +4°C 推荐的长期储存条件: -20°C 储存信息: Stable for 12 months at -20°C
纯化方式Affinity purification Protein A

背景信息

Product Specifications Anti-CD63 antibody [EPR5702] - Late Endosome Marker (ab134045) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in IHC-P, WB in human samples. Anti-CD63 antibody [EPR5702] - Late Endosome Marker (ab134045) specifically detects CD63 (UniProt ID: P08962; Molecular weight: 26kDa) and is sold in 100 µL and 1 mL selling sizes. Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-CD63 antibody [EPR5702] - Late Endosome Marker (ab134045) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-CD63 antibody [EPR5702] - Late Endosome Marker (ab134045) has been confirmed by testing in knockout samples. Anti-CD63 antibody [EPR5702] - Late Endosome Marker (ab134045) has been cited over 379 times in peer reviewed journals and is trusted by the scientific community. Anti-CD63 antibody [EPR5702] - Late Endosome Marker (ab134045) has 5 independent reviews from customers. Related Products Conjugation-ready, carrier free format available for antibody clone EPR5702 - ab215821. Antibody clone EPR5702 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 647 ( ab309976, ab316180 ). Target Information CD63, also known as LAMP3 or Granulophysin, is a member of the tetraspanin family and is widely expressed on the surface of various cells, including macrophages and lymphocytes. It plays a crucial role in the formation and release of exosomes. CD63 (Granulophysin) is highly expressed in various tumor cells and also impacts the tumor microenvironment (TME) by regulating cell communication. Additionally, CD63 facilitates the degradation of the extracellular matrix, aiding in tumor cell invasion and metastasis. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies. Species reactivity Rat: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.

文献引用 (712)

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一种双功能工程化外泌体负载水凝胶可改变内源性神经干细胞的命运,用于脊髓损伤修复。

Li Wenxiang, Zhang Wencan, Zheng Han, Zhang Yang, Feng Yanbin, Xie Yujia, Liu Xuanrui, Liu Mingshan, Kong Xiaohong, Ran Ning, Feng Shiqing

Extracellular Vesicle-Mediated O-GlcNAcase Transfer Drives Neuronal Necroptosis to Facilitate Gallbladder Cancer Perineural Invasion.

细胞外囊泡介导的 O-GlcNAcase 转移驱动神经元坏死,从而促进胆囊癌的神经周围侵袭。

Zhao Jingwei, Zhu Jiayun, Yang Ziyi, Zhai Yangyang, Zhao Cheng, Lu Zhichao, Shen Danyang, Tang Qiuyi, Song Xiaoling, Jiang Lin, Dai Wenting, Wang Yaxuan, Zhu Yidi, Shi Liuqing, Bao Runfa, Geng Zhimin, Wang Ziheng, Liu Shilei, Gong Wei

Systemic Inflammation Modulates Clearance and Drives Extra-Hepatic Distribution of Extracellular Vesicles.

全身炎症调节细胞外囊泡的清除并驱动其向肝外分布。

Pavlova Svetlana, Mamand Doste R, Görgens André, Zickler Antje M, Zheng Wenyi, Liang Xiuming, Wiklander Oscar P B, Abedi-Valugerdi Manuchehr, Van Wonterghem Elien, Xie Junhua, Niu Zheyu, Roudi Samantha, Yan Dongnan, Makkar Ruhani, Zhou Guannan, Imami Koshi, Wood Matthew J A, Vandenbroucke Roosmarijn E, Gupta Dhanu, Andaloussi Samir El

Tissue-Derived Extracellular Vesicles Define Diagnostic Biomarkers for Renal Cell Carcinoma.

组织来源的细胞外囊泡可作为肾细胞癌的诊断生物标志物。

Wu Xinrui, Zhou Jiale, Jiang Chen, Chen Wenjin, Peng Zehong, Wu Tianyang, Ge Yang, Du Xinxing, Hu Cong, Wu Xiaorong, Huang Jiwei, Zhang Jin, Cui Xingang, Xue Wei, Chen Yonghui, Dong Liang

Mitochondrial protein-enriched artificial nanovesicles: mitochondrial recovery and antioxidation for diabetic wound treatment.

富含线粒体蛋白的人工纳米囊泡:用于糖尿病伤口治疗的线粒体恢复和抗氧化作用。

Xia Junhao, Wang Lizhi, Song Yang, Zhu Mengru, Xu Yu, Liu Jia, Guan Xin, Zhang Qingwen, He Keman, Wang Fengya, Liu Lukuan, Liu Jing

Programmable iPSC-derived CAR-NK vesicles remodel the immune microenvironment and eradicate tumors

可编程的iPSC衍生CAR-NK囊泡重塑免疫微环境并根除肿瘤

Hao Zhang,Shenglong Li,Chongzhong Liu,Xiangdong Gongye,Han Li,Yiyi Ji,Cheng-Wei Ju,Wenzhen Jia,Xing Niu,Yujing Guan,Xiangyu Zhai,Bin Jin,Peng Xia

Engineered M2 macrophage-derived extracellular vesicles reprogram mitochondrial metabolism to alleviate temporomandibular joint cartilage degeneration.

工程化的 M2 巨噬细胞衍生的细胞外囊泡重编程线粒体代谢,以缓解颞下颌关节软骨退化。

Ge Weiwen, Qi Lei, Wang Yun, Wang Jing, Fang Xin, Lei Shixue, Lin Dan, Zhang Lei, Zhang Shanyong

Dengue virus harnesses mosquito Syntenin to load and secrete viral RNA into salivary exosomes.

登革病毒利用蚊子唾液中的 Syntenin 蛋白将病毒 RNA 装载并分泌到唾液外泌体中。

Rachenne Florian, Schneider Norman, Rey-Cadilhac Félix, Serrato-Pomar Idalba, Pruvost Lauryne, Di Pietro Laura, Dainat Jacques, Vernet Audrey, Cazevieille Chantal, Ancelin Aurélie, Lai Kee Him Joséphine, Jansen Sander, Miot Elliott F, Fraering Jérémy, Simon Laurianne, Missé Dorothée, Morille Marie, Hammann Philippe, Seveno Martial, Urbach Serge, Dallmeier Kai, Marois Éric, Pompon Julien

Exosome RAB10 inhibits JAK1/STAT1 to hinder macrophage M1 polarization and promote tumor immune escape.

外泌体 RAB10 抑制 JAK1/STAT1,从而阻碍巨噬细胞 M1 极化并促进肿瘤免疫逃逸。

Guohui Tang, Bo Pang, Liu Yuting, Xu Shaopeng, Ruonan Li, Chengle Zhu, Qiong Wu, Ruorong Ran, Cai Haotian, Wenrui Wang, Changjie Chen, Qingling Yang

Curcumin pretreatment enhances the capacity of BMSC exosomes to attenuate renal ischemia-reperfusion injury by ferroptosis suppression via miR-16-5p/Smad3/Mb axis.

姜黄素预处理通过 miR-16-5p/Smad3/Mb 轴抑制铁死亡,增强 BMSC 外泌体减轻肾脏缺血再灌注损伤的能力。

Chen Bingyi, Chen Jinxing, Shen Zekun, Liu Shuang, Mei Yifan, Cai Hui, Li Kai, Peng Ziyang, Zhang Liwei, Wang Weiyi, Lu Shaoying
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