Anti-NLRP3 antibody [EPR23073-96] (Ab270449)

Cias1, Mmig1, Nalp3, Pypaf1, Nlrp3, Cold autoinflammatory syndrome 1 protein homolog, Cryopyrin, Mast cell maturation-associated-inducible protein 1, PYRIN-containing APAF1-like protein 1

反应种属:Mouse
抗原名称:Nlrp3
应用:WB, IF/ICC, IP

详细信息

免疫原The exact immunogen used to generate this antibody is proprietary information.
宿主/亚型Rabbit / IgG
抗体类型Monoclonal
产品形式Liquid
纯化方式Affinity purification Protein A
储存缓冲液pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
储存条件运输条件: Conditional Ambient 推荐的短期储存时间: 1-2 weeks 推荐的短期储存条件: +4°C 推荐的长期储存条件: -20°C 储存信息: Avoid freeze / thaw cycle
无载体蛋白No

特异性

NLRP3 is related with inflammation and is cell-type dependent. This antibody detects no signal or very weak signal in most normal natural samples. Stimulation may be required to allow detection of the NLRP3 protein in most samples, as described in the literature (PMID: 29070054, 29434227, and 22569257).

背景信息

What is this antibody validated in? Anti-NLRP3 antibody [EPR23073-96] (ab270449) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry/immunofluorescence (ICC/IF) in Mouse samples. What is the molecular weight of NLRP3? Anti-NLRP3 [EPR23073-96] (ab270449) specifically detects a band for NLRP3 (UniProt: Q8R4B8) at a molecular weight of 118kDa. Trusted by the scientific community Anti-NLRP3 [EPR23073-96] (ab270449) was first used in a scientific publication in 2020 and has been cited over 20 times in peer-reviewed journals. Specificity confirmed The specificity of Anti-NLRP3 antibody [EPR23073-96] (ab270449) has been confirmed by Western blot testing in Nlrp3 Knockout Mouse BMDCs. Other related products We have a range of other formats of antibody clone [EPR23073-96] also available for your convenience: ab270449, Carrier free - ab272702 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 20µl. Discover our selection of trial-size antibodies.

文献引用 (91)

Spatially selective clearance of inflammation-mediated reactive oxygen species in injured kidney cells.

空间选择性清除受损肾细胞中炎症介导的活性氧。

Xie Maowei, Fu Xin, Lan Yufei, Zhang Yuping, Li Haixin, Su Yan, Zhou Kun, Zhang Ying, Ding Xuejing, He Jian, Mao Zhilei

Meningeal lymphatic vessel dysfunction exacerbates brain injury in CVST mice via endoplasmic reticulum and oxidative stress pathways.

脑膜淋巴管功能障碍通过内质网和氧化应激途径加剧 CVST 小鼠的脑损伤。

Ying Jianbin, Li Jun, Wu Xianqun, Chen Xuanjie, Zhang Hao, Wei Liangfeng, Jing Junjie, Wang Shousen

Alisol F 24-acetate attenuated metabolic dysfunction-associated steatohepatitis by targeting the KEAP1/NRF2-mediated macrophage pyroptosis.

Alisol F 24-乙酸酯通过靶向 KEAP1/NRF2 介导的巨噬细胞焦亡来减轻代谢功能障碍相关的脂肪性肝炎。

Dong Zhiwu, Huang Keliang, Wu Weiyi, Xing Lianxiang, Zhang Ying, Zhang Xin, Yang Wenwei, Zhao Kewen

Forsythoside A Alleviates Neuroinflammatory Damage via Inhibiting TLR4/NF-κB/NLRP3 Activation-Induced Astrocyte Pyroptosis in Cerebral Ischemia-Reperfusion.

连翘苷A通过抑制TLR4/NF-κB/NLRP3激活诱导的星形胶质细胞焦亡来减轻脑缺血再灌注中的神经炎症损伤。

Guo Yupeng, Dong Xuanwei, Liu Min, Wang Jianxin, Guo Shewei

Limosilactobacillus fermentum 21 N1 Mitigates Candida albicans-Induced Vulvovaginal Candidiasis and Suppresses NLRP3 Inflammasome Activation in a Mouse Model.

Limosilactobacillus fermentum 21 N1 可减轻白色念珠菌引起的阴道念珠菌病,并在小鼠模型中抑制 NLRP3 炎症小体的激活。

Lim Eun Yeong, Kim Gun-Dong, Hong Geun-Hye, Lee So-Young, Lee So-Young, Shin Hee Soon

Huazhuo Decoction Contributes to Immune Homeostasis and Attenuates Neuronal Inflammation and Demyelination in a Mouse Model of Multiple Sclerosis.

华卓汤有助于维持免疫稳态,并能减轻多发性硬化症小鼠模型中的神经元炎症和脱髓鞘。

Wu Jing-Ying, Zhang Juan, Xu Shan, Qian Shi-Yan, Zha Zheng, Hu Jia-Ling, Yang Jiang-Li, Zhang Feng-Xia, Zheng Guo-Qing

The sphingolipid metabolite sphingosine protects against hypertension by targeting metabolic-inflammatory crosstalk via the NLRP3 inflammasome.

鞘脂代谢物鞘氨醇通过 NLRP3 炎症小体靶向代谢炎症串扰来预防高血压。

Li Wenjun, Zhou Dan, Ji Yanmei, Yang Meirong, Yang Yunhong, Dao Mengyao, He Xianyu, Jin Xingfang

Signal-induced NLRP3 phase separation initiates inflammasome activation.

信号诱导的NLRP3相分离启动炎症小体激活

Zou Gonglu, Tang Yuluan, Yang Jie, Fu Shuo, Li Yuheng, Ren Xuanyao, Zhou Nanhai, Zhao Wenlong, Gao Juyi, Ruan Ziran, Jiang Zhengfan

Targeting NLRP3/caspase-1/GSDMD to treat inner ear injury from labyrinthine hemorrhage.

靶向 NLRP3/caspase-1/GSDMD 治疗迷路出血引起的内耳损伤。

Wu Qiong, Xu Mingwei, Yao Yuan, Gong Tianyu, Zhang Qin, Jin Yulian, Yang Jun, Zhang Qing

Detection and Proinflammatory Effects of BTEX within the Human Atherosclerotic Plaque.

BTEX在人类动脉粥样硬化斑块中的检测及其促炎作用。

Marfella Raffaele, Carreras Francesca, Prattichizzo Francesco, La Grotta Rosalba, Pellegrini Valeria, Sardu Celestino, D'Onofrio Nunzia, Barbieri Michelangela, Municinò Maurizio, Siniscalchi Mario, Spinetti Fabio, Vigliotti Gennaro, Vecchione Carmine, Carrizzo Albino, Accarino Giulio, Squillante Antonio, Spaziano Giuseppe, Mirra Davida, Esposito Renata, Fenti Angelo, Galoppo Simona, Canzano Silvana, Marfella Ludovica Vittoria, Falco Giovanni, Balestrieri Maria Luisa, Mauro Ciro, Ceriello Antonio, Landrigan Philip J, D'Agostino Bruno, Iovino Pasquale, Paolisso Giuseppe
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