Anti-Nrf2 antibody (Ab137550)

Anti-Nrf2 antibody (ab137550) is a rabbit polyclonal antibody and is validated for use in ChIP, IP, WB in human, mouse, rat samples. Anti-Nrf2 antibody (ab137550) has been cited over 408 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-Nrf2 antibody (ab137550) has high sensitivity and specificity. The specificity of Anti-Nrf2 antibody (ab137550) has been confirmed by testing in knockout samples. Anti-Nrf2 antibody (ab137550) has 7 independent reviews from customers. Anti-Nrf2 antibody (ab137550) specifically detects Nrf2 (UniProt ID: Q16236; Molecular weight: 68kDa) and is sold in 50 µL selling sizes. NRF2 (Nuclear Factor Erythroid 2-Related Factor 2) is a transcription factor that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. It plays a crucial role in cellular defense mechanisms. Dysregulation of NRF2 has been implicated in various diseases, including neurodegenerative disorders like Alzheimer's (AD) and Parkinson's disease (PD), where oxidative stress and inflammation are key pathological features. NRF2 is bound to ubiquitin when it is the nucleus so MW would be higher than cytoplasm. Please note Nrf2 antibody (ab137550) detects no signal in most untreated samples for WB. Stimuli treated samples are recommended. Nrf2 expression is stimulated by oxidative stress, electrophiles and chemical activators (PMID: 25761198, PMID: 27638861 and PMID: 28587109). WB protocol info included in legend for MDA-MB-231 nuclear extract treated with 30 μM tBHQ for 4 hours (+). Abcam recommended secondaries - Goat Anti-Rabbit HRP ( ab205718 ) and Goat Anti-Rabbit Alexa Fluor®488 ( ab150077 ). Or search our wide range of secondary antibodies for use with your experiment.