Anti-CD45 antibody (Ab10558)
CD45, PTPRC, Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, T200, L-CA
详细信息
背景信息
Anti-CD45 antibody (ab10558) is a rabbit polyclonal antibody and is validated for use in Flow Cyt (Intra), IHC-P, WB in human samples. Anti-CD45 antibody (ab10558) has been cited over 450 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-CD45 antibody (ab10558) has high sensitivity and specificity. Anti-CD45 antibody (ab10558) has 56 independent reviews from customers. Anti-CD45 antibody (ab10558) specifically detects CD45 (UniProt ID: P08575; Molecular weight: 145kDa) and is sold in 100 µg selling sizes. CD45, also known as the leukocyte common antigen, is a transmembrane protein tyrosine phosphatase crucial for immune cell signaling. It exists in multiple isoforms, such as CD45RA and CD45RO, which help distinguish between different immune cell types and their functional states. CD45 plays a significant role in regulating lymphocyte development, activation, and homeostasis. Alterations in CD45 expression or function are linked to various immunodeficiencies and autoimmune disorders, highlighting its importance in maintaining immune balance. Autoimmune diseases related to CD45 involve alterations in the expression or function of this protein, which can disrupt normal immune cell signaling and lead to immune system dysregulation.
文献引用 (567)
Epigenetic memory of colitis promotes tumour growth.
结肠炎的表观遗传记忆促进肿瘤生长。
GFER Represents a Target for Dual Disruption of Redox Homeostasis and Reactivation of the Immune Response in Pancreatic Adenocarcinoma.
GFER 代表了胰腺腺癌中氧化还原稳态破坏和免疫反应重新激活的双重靶点。
Mechanical rejuvenation of senescent stem cells and aged bone via chromatin remodeling.
通过染色质重塑实现衰老干细胞和老化骨骼的机械再生。
Tenascin C(+) myofibroblasts exacerbate vascular neointimal hyperplasia by propagation of nerve-macrophage interactions in mice.
Tenascin C(+) 肌成纤维细胞通过促进小鼠体内神经-巨噬细胞相互作用，加剧血管内膜增生。
Cancer cell-intrinsic inflammasome protein ASC links innate immunity with mitochondrial metabolism in driving pancreatic cancer.
癌细胞固有炎症小体蛋白ASC将先天免疫与线粒体代谢联系起来，从而驱动胰腺癌的发生发展。
A "Hot Spring" Mimetic Aerogel Loaded with Multiple Amino Acids Modulates the Chronic Inflammatory Microenvironment Through Metabolic Reprogramming.
一种负载多种氨基酸的“温泉”模拟气凝胶通过代谢重编程调节慢性炎症微环境。
Stress-Programmed Immune Niches Fuel TNFR2+ Treg Activation and Drive Neoadjuvant Chemotherapy Resistance in Breast Cancer.
应激编程的免疫微环境促进 TNFR2+ Treg 激活，并驱动乳腺癌新辅助化疗耐药性。
Targeted AAV6 gene therapy restores corneal endothelial function in three hereditary corneal dystrophies.
靶向 AAV6 基因疗法可恢复三种遗传性角膜营养不良症患者的角膜内皮功能。
Comprehensive single-cell metabolic profiling identifies targets to sensitize triple-negative breast cancer to chemo-immunotherapy.
全面的单细胞代谢谱分析确定了可增强三阴性乳腺癌对化疗免疫疗法敏感性的靶点。
ADAM17-dependent Autocrine and Paracrine Signaling Promotes Pancreatic Premalignant Progression.
ADAM17依赖的自分泌和旁分泌信号促进胰腺癌前病变进展。
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