Anti-CD3 antibody [CD3-12] (Ab11089)
CD3e, T3E, CD3E, T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain
详细信息
特异性
IHC-P is not recommended in Human samples.
背景信息
Product Specifications Anti-CD3 antibody [CD3-12] (ab11089) is a rat recombinant monoclonal antibody and is validated for use in in human, mouse, rat samples. Anti-CD3 antibody [CD3-12] (ab11089) specifically detects CD3 (UniProt ID: P07766; Molecular weight: 21kDa) and is sold in 100 µg and 1 mg selling sizes. Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-CD3 antibody [CD3-12] (ab11089) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-CD3 antibody [CD3-12] (ab11089) has been cited over 104 times in peer reviewed journals and is trusted by the scientific community. Anti-CD3 antibody [CD3-12] (ab11089) has 18 independent reviews from customers. Related Products Conjugation-ready, carrier free format available for antibody clone CD3-12 - ab255972. Antibody clone CD3-12 is also available pre-conjugated to a variety of labels for your convenience - FITC ( ab34722 ). Target Information CD3, or Cluster of Differentiation 3, is a protein complex and T cell co-receptor that plays a crucial role in the activation of T cells, which are essential for the immune response. In oncology, CD3 is particularly significant due to its involvement in cancer immunotherapy. CD3 is targeted to enhance the body's ability to fight cancer. Bispecific antibodies (bsAbs) that target CD3 and a tumor antigen bring T cells into close proximity with cancer cells, promoting their destruction. This product has switched from a hybridoma to recombinant production method on 1st November 2024. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.
文献引用 (158)
Positioning and reversible suppression of CCR7(+) dendritic cells in perivascular tumor niches shape cancer immunity.
CCR7(+)树突状细胞在血管周围肿瘤微环境中的定位和可逆抑制塑造了癌症免疫。
Disruption of tRNA threonylation triggers RIG-I mediated anti-tumour immune response.
tRNA苏氨酰化作用的破坏会触发RIG-I介导的抗肿瘤免疫反应。
Cancer cell-intrinsic inflammasome protein ASC links innate immunity with mitochondrial metabolism in driving pancreatic cancer.
癌细胞固有炎症小体蛋白ASC将先天免疫与线粒体代谢联系起来,从而驱动胰腺癌的发生发展。
SHANK3 and beta-synuclein are novel blood-based biomarkers for the Phelan-McDermid Syndrome: a pilot study.
SHANK3 和 β-突触核蛋白是 Phelan-McDermid 综合征的新型血液生物标志物:一项初步研究。
Pauci-Immune Endocapillary Proliferative Glomerulonephritis With Glomerular M2 Macrophage Infiltration.
少免疫性毛细血管内增生性肾小球肾炎伴肾小球M2巨噬细胞浸润。
Complement contributes to ICI-triggered sialadenitis and predicts ICI efficacy.
补体可导致 ICI 诱发的涎腺炎,并可预测 ICI 的疗效。
PCBP1 binding to single-stranded poly-cytosine motifs enhances cGAS sensing and impairs breast cancer development.
PCBP1 与单链多胞嘧啶基序的结合增强了 cGAS 的感知,并损害了乳腺癌的发展。
Therapeutic Effect and Underlying Mechanism of Blue Mussel (Mytilus galloprovincialis) Oil on Adjuvant-Induced Rheumatoid Arthritis in Rats.
蓝贻贝(Mytilus galloprovincialis)油对佐剂诱导的大鼠类风湿性关节炎的治疗效果及其潜在机制。
Targeting peptidyl-arginine deiminase 4 suppresses SARS-CoV-2 replication and modulates the inflammatory response.
靶向肽基精氨酸脱亚胺酶 4 可抑制 SARS-CoV-2 复制并调节炎症反应。
Recombinant duck enteritis virus harboring the hemagglutinin genes of influenza virus rapidly induces specific cellular immunity in ducks.
含有流感病毒血凝素基因的重组鸭肠炎病毒可迅速诱导鸭产生特异性细胞免疫。
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