用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| ELISA | 1:1000-1:2000 |
| ELISA(Det) | 1:1000-1:10000 |
推荐稀释说明
Optimal concentrations/dilutions should be determined by the end user.
详细信息
特异性
Human IL-6
制备方法
This product is a recombinant monoclonal antibody expressed from HEK293 cells.
运输条件
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
背景信息
Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined as an essential role in directing the transition from innate to acquired immunity. Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy Full Name interleukin 6 Research Areas Neuroinflammation Cancer Drug Targets Related Pathways IL17 signaling pathway References Heinrich PC. et al. (2003). Principles of interleukin-6-type cytokine signalling and its regulation. Biochem J. 374: 1-20. Rose-John S, et al. (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets. 11(5): 613-24. Dinh W, et al. (2009) Elevated plasma levels of TNF-alpha and interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders. Cardiovasc Diabetol. 8:58.