用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| IHC-P | 1:500-1:2000 |
推荐稀释说明
Optimal concentrations/dilutions should be determined by the end user.
详细信息
特异性
Human EGFR
制备方法
Produced in rabbits immunized with E. coli-derived Human EGFR fragment, and purified by antigen affinity chromatography.
运输条件
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
背景信息
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently. Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy Full Name epidermal growth factor receptor Research Areas Cancer Drug Targets Receptor Tyrosine Kinases (RTKs) Related Pathways EGFR Signaling Pathway Jak-Stat Signaling Pathway References Schlessinger, J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103(2): 211-25. Giaccone, G. (2005) HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy. Ann. Oncol. 16(4): 538-48. Yarden, Y., et al. (2001) Untangling the ErbB signalling network. Nat. Rev. Mol. Cell. Biol. 2(2): 127-37.