Anti-CD3 epsilon antibody [SP7] (Ab16669)

CD3e, T3E, CD3E, T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain

反应种属:Human, Mouse, Rat
抗原名称:CD3E
应用:WB, IHC, FCM, MIHC

详细信息

免疫原The exact immunogen used to generate this antibody is proprietary information.
宿主/亚型Rabbit / IgG
抗体类型Monoclonal
产品形式Liquid
纯化方式Affinity purification Protein A
储存缓冲液pH: 7.2 - 7.4 Preservative: 0.1% Sodium azide Constituents: PBS, 1% BSA
储存条件运输条件: Conditional Ambient 推荐的短期储存条件: +4°C 推荐的长期储存条件: -20°C 储存信息: Avoid freeze / thaw cycle
无载体蛋白No

背景信息

Anti-CD3 epsilon antibody [SP7] (ab16669) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), IHC-P, WB and mIHC. Anti-CD3 epsilon antibody [SP7] (ab16669) was first used in a scientific publication in 2008 and has been cited over 722 times in peer reviewed journals. It's performance in IHC in human, mouse and rat samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-CD3 epsilon antibody [SP7] (ab16669) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-CD3 epsilon antibody [SP7] (ab16669) has 79 independent reviews from customers. Anti-CD3 epsilon antibody [SP7] (ab16669) specifically detects CD3 epsilon (UniProt ID: P07766; Molecular weight: 21kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (100 µL, 500 µL and 1 mL). Conjugation-ready, carrier free format available for antibody clone SP7 - ab205228. Anti-CD3 epsilon antibody [SP7] (ab16669) is a clone from the portfolio of Spring Bioscience (Roche) SP clones which have been optimised for immunohistochemistry (IHC). Top cited recombinant antibody on the market with >988 citations. SP7 has received >79 reviews. CD3 epsilon (CD3ε) is a crucial component of the T-cell receptor (TCR) complex. It plays a key role in T-cell activation and signal transduction by coupling antigen recognition to intracellular signalling pathways. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.

文献引用 (965)

Myofibroblast programming blocks differentiation of TLS-organizing fibroblastic reticular cells in pancreatic cancer.

肌成纤维细胞编程阻断胰腺癌中TLS组织成纤维网状细胞的分化。

Kirschstein Elijah, Harder Olivia, Krull Jordan, Sikorski Madison, Khanal Shrijan, Mack Morgan, Ware Carl F, Evans Elizabeth, Gough Michael J, Ma Qin, Chen Wei, Young Kristina H, Gunderson Andrew J

IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma.

IFNγ依赖性代谢重编程抑制黑色素瘤中不成熟的、促转移的淋巴状态。

Mapping cellular targets of covalent cancer drugs in the entire mammalian body.

绘制共价抗癌药物在哺乳动物体内的细胞靶点图谱。

Pang Zhengyuan, Leung Verina H, Wang Cailynn C, Attarpour Ahmadreza, Rinaldi Anthony, Shen Hanbing, Moya-Garzon Maria Dolores, Sigua Logan H, Rammel Claire, Selke Alexandra, Glynn Christopher, Yender Melaina, Xu Senhan, Moslehi Javid J, Wu Peng, Long Jonathan Z, Goubran Maged, Cravatt Benjamin F, Ye Li

Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models.

对全球小鼠甲基化组图谱的研究揭示了儿童癌症模型中亚型特异性拷贝数改变。

Schoof Melanie, Zheng Tuyu, Sill Martin, Imle Roland, Cais Alessia, Altendorf Lea, Fürst Alicia, Hofmann Nina, Ernst Kati, Vonficht Dominik, Chan Kenneth Chun-Ho, Holland-Letz Tim, Postlmayr Andreas, Shiraishi Ryo, Wang Wanchen, Morcavallo Alaide, Spohn Michael, Göbel Carolin, Niesen Judith, Peter Levke-Sophie, Bourdeaut Franck, Han Zhi-Yan, Pei Yanxin, Murad Najiba, Swartling Fredrik J, Taylor Jessica, Yadav Monika, Gibson Garrett R, Gilbertson Richard J, Dottermusch Matthias, Roy Rajanya, Kerl Kornelius, Glass Rainer, Cheng Jiying, Horstmann Martin A, Wolters-Eisfeld Gerrit, Zhao Haotian, Sturm Dominik, Yadav Viveka Nand, Chesler Louis, Haas Simon, Weiss William A, Northcott Paul A, Kutscher Lena M, Guerreiro Stucklin Ana, Ayrault Olivier, Neumann Julia E, Kawauchi Daisuke, Jones David T W, Pajtler Kristian, Banito Ana, Pfister Stefan M, Schüller Ulrich, Zuckermann Marc

Chiral metal nanozyme-enabled SOD2 activation and siRNA delivery cooperatively mitigating chronic heart failure.

手性金属纳米酶激活 SOD2 和 siRNA 递送,协同缓解慢性心力衰竭。

Wang Zekun, Zhang Ruofei, Hu Yanyu, Song Qile, Fu Xiaoyan, Wang Yifan, Chen Mei, Fan Kelong, Fan Cundong, Sun Dongdong

Aminated fullerene-based nanoplatform enables synergistic VEGFR2-targeted anti-angiogenesis and tumor immunotherapy.

基于氨基化富勒烯的纳米平台可实现协同的 VEGFR2 靶向抗血管生成和肿瘤免疫治疗。

Huo Jiawei, Wang Yijun, Liu Lei, Li Jie, Yang Libin, Wang Zehu, Li Bowen, Zhang Weixin, Wang Xin, Siringan Mark John, Li Xue, Zhao Ruili, Huang Dongling, Liao Wanwen, Wang Chunru, Bai Chunli

PA28γ-containing tumor-derived exosomes promote T-cell dysfunction in head and neck squamous cell carcinoma.

含有 PA28γ 的肿瘤来源外泌体可促进头颈部鳞状细胞癌中的 T 细胞功能障碍。

Wang Ying, Zhang Shiyu, Yang Yang, Wang Yimei, Zhang Yingxin, Liu Ming, Zeng Xin, Ji Ning, Sun Silu, Li Chunjie, Zhao Yuwei, Zhou Xikun, Chen Qianming, Li Jing

Weaning drives microbiome-mediated epigenetic regulation to shape immune memory in mice.

断奶驱动微生物组介导的表观遗传调控,从而塑造小鼠的免疫记忆。

Yang Li, Peery Robert C, Zhou Shirui, Chen Xiaomin, Farmer Leah M, Gutierrez Fabiola, Fowler Stephanie, Zhang Lanjing, Salamat Julia M, Riggins Karen, Shi Jiejun, Shen Lanlan

HERV-K TM Subunit Elicits CD8(+) T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC.

HERV-K TM 亚基通过靶向 AML 和 PDAC 中的 CD3 共受体 α 引发 CD8(+) T 细胞无反应性和肿瘤免疫逃逸。

Li Mengyuan, Zheng Shuwen, Gong Qinyuan, Wu Zhaoxing, Lei Wen, Cao Wanyue, Wang Ping, Zhang Xuzhao, Qian Wenbin, Liang Yun, Lu Ying, Li Fenglin, Zhang Qi, Xu Rongzhen

Metabolic Reprogramming of T Cells by Dual UCP2 and IL-17 Blockade Enhances Immunity Against Pancreatic Cancer.

通过 UCP2 和 IL-17 双重阻断对 T 细胞进行代谢重编程,增强对胰腺癌的免疫力。

Liu Chuan-Teng, Yeh Chun-Chieh, Wu Tsai-Chen, Lin Chia-Hsin, Kuo Yi-Ting, Iwakura Yoichiro, Day Yuan-Ji, Drake Charles, Radojcic Vedran, Song Ying-Chyi, Wu Heng-Hsiung, Yen Hung-Rong
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