Anti-CD8 alpha antibody [C8/144B] (Ab17147)
CD8a, MAL, CD8A, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2
用户验证的应用
推荐稀释比例
- IHC-P1/50 - 1/100 Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.
- Flow Cyt1/100 ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
详细信息
背景信息
Product Specifications Anti-CD8 alpha antibody [C8/144B] (ab17147) is a mouse monoclonal antibody and is validated for use in Flow Cyt, IHC-P in human samples. Anti-CD8 alpha antibody [C8/144B] (ab17147) specifically detects CD8 alpha (UniProt ID: P01732; Molecular weight: 24kDa) and is sold in 500 µL selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-CD8 alpha antibody [C8/144B] (ab17147) has high sensitivity and specificity. Anti-CD8 alpha antibody [C8/144B] (ab17147) has been cited over 103 times in peer reviewed journals and is trusted by the scientific community. Anti-CD8 alpha antibody [C8/144B] (ab17147) has 9 independent reviews from customers. Target Information CD8 alpha is a transmembrane glycoprotein acting as a co-receptor for the T-cell receptor (TCR), predominantly present on cytotoxic T cells. It is vital for T cell signaling and cytotoxic function by binding to MHC class I molecules, supporting the immune response against infected or cancerous cells. CD8 alpha is linked to various diseases, especially those related to immune system dysfunction
文献引用 (123)
MiR-1290 in natural killer cell derived extracellular vesicles: a pathogenic mediator of lupus nephritis and therapeutic target for th17 regulation.
自然杀伤细胞衍生的细胞外囊泡中的 miR-1290：狼疮性肾炎的致病介质和 th17 调控的治疗靶点。
Dual regulation of CXCR6(+)CD8(+) T cells modulates cytotoxic and exhaustion-associated programs during prostate cancer progression.
CXCR6(+)CD8(+) T 细胞的双重调控在前列腺癌进展过程中调节细胞毒性和耗竭相关程序。
Compartment-specific GLUT1 patterns in colorectal liver metastases: invasive-margin GLUT1 associates with outcome in solitary disease.
结直肠肝转移中区室特异性 GLUT1 模式：侵袭边缘 GLUT1 与孤立性疾病的预后相关。
Analysis of prognostic factors related to pulmonary metastasectomy for hepatocellular carcinoma following liver resection.
肝切除术后肝细胞癌肺转移瘤切除术相关预后因素分析。
The CXCL10-CXCR3 Axis Induces Tumor-Associated Neutrophils to Interfere with CTLs-Mediated Antitumor Activity in EBV-Associated Epithelial Cancers.
CXCL10-CXCR3轴诱导肿瘤相关中性粒细胞干扰CTL介导的EBV相关上皮癌的抗肿瘤活性。
Fibronectin Fibers Progressively Lose Their Tension in Invasive Human Breast Carcinoma while Being Tensed in DCIS and Healthy Breast Tissue.
在浸润性人类乳腺癌中，纤连蛋白纤维逐渐失去张力，而在导管原位癌和健康乳腺组织中，纤连蛋白纤维则保持张力
Targeting CD39 boosts PD-1 blockade antitumor therapeutic efficacy via strengthening CD8â+âTILs function and recruiting B cells in cervical cancer.
靶向 CD39 可增强 PD-1 阻断抗肿瘤治疗效果，其机制是通过增强 CD8+TILs 功能和募集 B 细胞来治疗宫颈癌
ARID1A Loss plus CD8+ T-Cell Infiltration Associate with Favorable Clinical Outcomes in Urothelial Carcinoma.
ARID1A 缺失加上 CD8+ T 细胞浸润与尿路上皮癌的良好临床结果相关。
Multi-omics profiling reveals downregulated tumor lysine metabolism reshaping the immune microenvironment and therapeutic responses in hepatocellular carcinoma.
多组学分析揭示肿瘤赖氨酸代谢下调重塑肝细胞癌的免疫微环境和治疗反应。
Deep visual proteomics reveals DNA replication stress as a hallmark of signet ring cell carcinoma
深度视觉蛋白质组学揭示 DNA 复制压力是印戒细胞癌的标志
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