用户验证的应用
经验证应用
| 项目 | 详情 |
|---|---|
| Positive WB detected in | A549 cells, HeLa cells |
| Positive IF/ICC detected in | A431 cells, HaCaT cells |
| Positive FC (Intra) detected in | A431 cells |
详细信息
宿主/亚型Rabbit / IgG
抗体类型Recombinant
产品类型Antibody
产品形式Liquid
偶联物Unconjugated
纯化方式Protein A purfication
储存缓冲液PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
RRIDAB_3671393
UniProt IDP00533
Gene ID1956
背景信息
EGFR, also named as ERBB1, is a cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. The gene resides on chromosome 7p12, encoding a 170 kDa membrane-associated glycoprotein. Recent studies have shown EGFR plays a critical role in cancer development and progression, including cell proliferation, apoptosis, angiogenesis, and metastatic spread. Mutations in this gene are associated with lung cancer.