Anti-Histone H3 antibody - Nuclear Marker (Ab18521)

H3FA, HIST1H3A, H3C2, H3FL, HIST1H3B, H3C3, H3FC HIST1H3C, H3C4, H3FB, HIST1H3D, H3C6, H3FD, HIST1H3E, H3C7, H3FI, HIST1H3F, H3C8, H3FH, HIST1H3G, H3C10, H3FK, HIST1H3H, H3C11, H3FF, HIST1H3I, H3C12, H3FJ, HIST1H3J, HIST1H3C, H3FC, H3C1, Histone H3.1, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, Histone H3/l

反应种属:Human, Bovine, Yeast
抗原名称:H3C1
应用:WB, IHC, IF/ICC, IP

详细信息

免疫原The exact immunogen used to generate this antibody is proprietary information.
宿主/亚型Rabbit / IgG
抗体类型Polyclonal
产品形式Liquid
纯化方式Affinity purification Immunogen
储存缓冲液pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
储存条件运输条件: Blue Ice 推荐的短期储存时间: 1-2 weeks 推荐的短期储存条件: +4°C 推荐的长期储存条件: -20°C 储存信息: Avoid freeze / thaw cycle

特异性

ab18521 recognises unmodified and modified forms of histone H3

背景信息

Anti-Histone H3 antibody (ab18521) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IHC-P, IP, Western Blot in chinese hamster, human, mouse, rat samples. Anti-Histone H3 antibody (ab18521) has been cited over 83 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-Histone H3 antibody (ab18521) has high sensitivity and specificity. Anti-Histone H3 antibody (ab18521) has 7 independent reviews from customers. Anti-Histone H3 antibody (ab18521) specifically detects Histone H3 (UniProt ID: P68431; Molecular weight: 15kDa) and is sold in 100 µg selling sizes. Histone H3 is a fundamental protein involved in maintaining chromatin structure and regulating gene expression. Utilizing this antbody for histone h3 western blot techniques can significantly enhance the detection and study of post-translational modifications on Histone H3. Research indicates that these modifications play a crucial role in epigenetics, influencing various cellular processes and disease states. Histone H3 modifications regulate gene expression in cancer and other diseases. Abnormal modifications are linked to pediatric tumors, neurodevelopmental syndromes, and disrupted cellular functions.

文献引用 (110)

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Hammond Michael, Chmelová Ľubomíra, van Geelen-Kuenzel Natascha A, Maurya Anay K, Ferreira Eden R, Puente Vanesa, Cadena Lawrence Rudy, Záhonová Kristína, Dowle Adam, Mottram Jeremy C, Nowack Eva C M, Lukeš Julius, Yurchenko Vyacheslav

Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer.

连续的转录波和 NF-κB 驱动的染色质重塑直接导致药物诱导的癌症去分化。

Su Yapeng, Liu Chunmei, Lu Xiang, Chuang Hui-Yu, Li Guideng, Shao Shiqun, Kong Yan, Lee Jihoon W, Ng Rachel H, Wong Stephanie, Robert Lidia, Warden Charles, Liu Victoria, Chen Jie, Wang Zhuo, Qin Guangrong, Tang Yin, Cheng Hanjun, Ng Alphonsus H C, Chen Daniel, Peng Songming, Xue Min, Johnson Dazy, Xu Yu, Wang Jinhui, Wu Xiwei, Shmulevich Ilya, Shi Qihui, Levine Raphael, Ribas Antoni, Baltimore David, Guo Jun, Heath James R, Wei Wei

Repeat-rich RNA guides repetitive genomic elements into biomolecular condensates for heterochromatin organization and muscle integrity.

富含重复序列的 RNA 引导重复的基因组元件形成生物分子凝聚体,从而实现异染色质的组织和肌肉的完整性。

Choi Jinmi, Park Sangha, Kim Nahee, Kwon Soonho, Park Jinyoung, Lee Somin, Lee Hongmin, Kang Keonjin, Kim Taewan, Sul Jaehoon, Jo Dong-Gyu, Youn Hong-Duk, Cho Eun-Jung

BACE2 tunes lipid uptake through lipid transporters shedding supporting cancer cell proliferation.

BACE2 通过脂质转运蛋白的脱落来调节脂质吸收,从而支持癌细胞增殖。

Matafora Vittoria, Elhagh Alice, Morelli Alessandra, Tronci Laura, Cattaneo Angela, Conti Camilla, Casagrande Francesca, Farris Francesco, Bachi Angela

Argonaute CSR-1A promotes H3K9me3 maintenance to protect somatic development in offspring

Argonaute CSR-1A 促进 H3K9me3 维持以保护后代体细胞发育

Di Rao, Dengfeng Li, Lili Li, Junchao Xue, Shikui Tu, En-Zhi Shen

RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development.

RACK7 与 PRC2 复合物相互作用以调节星形胶质细胞发育

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FOXP1 phosphorylation antagonizes its O-GlcNAcylation in regulating ATR activation in response to replication stress

FOXP1磷酸化拮抗其O-GlcNAc糖基化,从而在复制应激反应中调节ATR激活。

Xuefei Zhu # ,Congwen Gao # ,Bin Peng # ,Jingwei Xue ,Donghui Xia ,Liu Yang ,Jiexiang Zhang ,Xinrui Gao ,Yilin Hu ,Shixian Lin ,Peng Gong ,Xingzhi Xu

p53 regulates DREAM complex-mediated repression in a p21-independent manner.

p53 以不依赖于 p21 的方式调节 DREAM 复合物介导的抑制

Agrawal Ritu, Sengupta Sagar

Exploring p53 isoforms: unraveling heterogeneous p53 tumor suppressor functionality in uveal melanoma.

探索 p53 亚型:揭示葡萄膜黑色素瘤中 p53 肿瘤抑制功能的异质性。

Bartolomei Laura, Ciribilli Yari, Brugnara Samuele, Reggiani Francesco, Moretta Gian Mario, Petito Mariangela, Marcaccini Elisa, Ambrosio Marianna, Mosci Carlo, Pfeffer Ulrich, Amaro Adriana, Monti Paola, Bisio Alessandra

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Sean Y Ng ,Andrew I Mikhail ,Stephanie R Mattina ,Salah A Mohammed ,Shahzeb K Khan ,Eric M Desjardins ,Changhyun Lim ,Stuart M Phillips ,Gregory R Steinberg ,Vladimir Ljubicic
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