Anti-p21 antibody [EPR18021] (Ab188224)
Cip1, Waf1, Cdkn1a, Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein, p21
详细信息
特异性
Expression levels of the target protein vary between different tissue/cell lines and in some cases induction may be required before a signal is observed.This antibody is not recommended for use in WB with tissue samples.
背景信息
Anti-p21 antibody [EPR18021] (ab188224) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P, IP and WB. Anti-p21 antibody [EPR18021] (ab188224) was first used in a scientific publication in 2017 and has been cited over 163 times in peer reviewed journals. It's performance in Western Blot in mouse samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-p21 antibody [EPR18021] (ab188224) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-p21 antibody [EPR18021] (ab188224) has 11 independent reviews from customers. Anti-p21 antibody [EPR18021] (ab188224) specifically detects p21 (UniProt ID: P39689; Molecular weight: 18kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL). Conjugation-ready, carrier free format available for antibody clone EPR18021 - ab232512. Antibody clone EPR18021 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor ® 488, Alexa Fluor ® 647, APC, PE ( ab237264, ab237265, ab313956, ab314287 ). p21 is a cyclin-dependent kinase inhibitor that regulates cell cycle progression, promoting cell cycle arrest in response to DNA damage. It plays a dual role in oncology by both suppressing tumor growth through cell cycle inhibition and contributing to cancer progression when localized in the cytoplasm. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.
文献引用 (265)
Cell cycle duration determines oncogenic transformation capacity.
细胞周期持续时间决定了其致癌转化能力
Delivering LINE1 antisense oligonucleotides via endothelial targeting extracellular vesicles to ameliorate myocardial infarction-induced cardiac senescence.
通过内皮细胞靶向细胞外囊泡递送 LINE1 反义寡核苷酸,以改善心肌梗死引起的心脏衰老
A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging
基于神经节苷脂的免疫检查点使衰老细胞能够在衰老过程中逃避免疫监视
High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan in preclinical models.
高内涵筛选发现灵芝酸 A 是一种抗衰老药物,可在临床前模型中预防细胞衰老并延长健康寿命
ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice
小鼠小胶质细胞中与 ALS/FTD 相关的 TBK1 缺陷会诱导类似衰老的小胶质细胞特征,并导致小鼠社交识别缺陷。
Regenerating aged bone marrow via a nitric oxide nanopump
利用一氧化氮纳米泵再生衰老骨髓
Extrusion of BMP2+ surface colonocytes promotes stromal remodeling and tissue regeneration
BMP2+表面结肠细胞的挤出促进基质重塑和组织再生。
Nephronectin (NPNT) is a Crucial Determinant of Idiopathic Pulmonary Fibrosis: Modulating Cellular Senescence via the ITGA3/YAP1 Signaling Axis.
肾连接蛋白 (NPNT) 是特发性肺纤维化的关键决定因素:通过 ITGA3/YAP1 信号轴调节细胞衰老
Genetically engineered chondrocyte-mimetic nanoplatform attenuates osteoarthritis by blocking IL-1β and restoring sirtuin-3.
基因工程软骨细胞模拟纳米平台通过阻断 IL-1β 和恢复 sirtuin-3 来减轻骨关节炎
Citrulline regulates macrophage metabolism and inflammation to counter aging in mice
瓜氨酸调节巨噬细胞代谢和炎症以对抗小鼠衰老
- 1
- 2
- 3
- 4
- 5
- 6
- 27